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Browsing Center for Life Sciences by Title

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  • Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells 
    Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M. (Neuroscience. Author manuscript; available in PMC, 2012-12-29)
    Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...
  • Role of membrane biophysics in Alzheimer’s–related cell pathways 
    Zhu, Donghui; Bungart, BrittaniL; Yang, Xiaoguang; Zhumadilov, Zhaxybay; Lee, James C-M.; Askarova, Sholpan (Frontiers inNeuroscience, 2015-05-27)
    P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the development and progression ...
  • Role of ROS in Aβ42 mediated cell surface P-selectin expression and actin polymerization 
    Tsoy, Andrey; Shalakhmetova, Tamara; Umbayev, Bauyrzhan; Askarova, Sholpan (Neurology Asia, 2014)
    P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the development and progression ...
  • Role of viruses in the development of breast cancer 
    Alibek, Kenneth; Kakpenova, Ainur; Mussabekova, Assel; Sypabekova, Marzhan; Karatayeva, Nargis (Infectious Agents and Cancer, 2013-09-02)
    The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated ...
  • RYR2 sequencing reveals novel missense mutations in a Kazakh Idiopathic ventricular tachycardia study cohort 
    Akilzhanova, Ainur; Guelly, Christian; Nuralinov, Omirbek; Nurkina, Zhannur; Nazhat, Dinara; Smagulov, Shalkhar; Tursunbekov, Azat; Alzhanova, Anar; Rashbayeva, Gulzhaina; Abdrakhmanov, Ayan; Dosmagambet, Sholpan; Trajanoski, Slave; Zhumadilov, Zhaxybay; Sharman, Almaz; Bekbosynova, Mahabbat (PLOS ONE. doi:10.1371/journal.pone.0101059, 2014)
    Channelopathies, caused by disturbed potassium or calcium ion management in cardiac myocytes are a major cause of heart failure and sudden cardiac death worldwide. The human ryanodine receptor 2 (RYR2) is one of the key ...
  • SCREENING OF ANTIMICROBIAL AND ADHESIVE ACTIVITY OF LACTOBACILLI ISOLATED FROM THE NATIONAL FOOD PRODUCTS FROM DIFFERENT DISTRICTS OF THE KARAGANDA REGION (KAZAKHSTAN) 
    Amirkhanova, Zhanerke; Akhmetova, Saule; Kozhakhmetov, Samat; Kushugulova, Almagul; Bodeeva, Rahat; Issina, Zauresh; Tusbayev, Marat (Scientific Foundation SPIROSKI, 2021-09-14)
    BACKGROUND: It is a national priority to look for new probiotic bacteria with highly active biological properties to create a new generation of probiotics, ferments, therapeutic, and prophylactic fermented milk products, ...
  • Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage 
    Kozhakhmetov, Samat S.; Zhumadilov, Zhaxybay; Kushugulova, Almagul R.; Bartolomaeus, Hendrik; Balogh, András; Yakoub, Mina; Homann, Susanne; Markó, Lajos; Höges, Sascha; Tsvetkov, Dmitry; Krannich, Alexander; Wundersitz, Sebastian; Avery, Ellen G.; Haase, Nadine; Kräker, Kristin; Hering, Lydia; Maase, Martina; Kusche-Vihrog, Kristina; Grandoch, Maria; Fielitz, Jens; Kempa, Stefan; Gollasch, Maik; Eckardt, Kai-Uwe; Dechend, Ralf; Rump, Lars Christian; Forslund, Sofia K.; Müller, Dominik N.; Stegbauer, Johannes; Wilck, Nicola (Wolters Kluwer Health; American Heart Association, 2018-12-04)
    Arterial hypertension and its organ sequelae show characteristics of T cell–mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, ...
  • The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults 
    Zhumadilov, Zhaxybay; Supiyev, Adil; Geldsetzer, Pascal; Manne-Goehler, Jennifer; Marcus, Maja-Emilia; Ebert, Cara; Wesseh, Chea S; Tsabedze, Lindiwe; Sturua, Lela; Bahendeka, Silver K; Sibai, Abla M; Quesnel-Crooks, Sarah; Norov, Bolormaa; Mwangi, Kibachio J; Mwalim, Omar; Wong-McClure, Roy; Mayige, Mary T; Martins, Joao S; Lunet, Nuno; Labadarios, Demetre; Karki, Khem B; Kagaruki, Gibson B; Jorgensen, Jutta M A; Hwalla, Nahla C; Houinato, Dismand; Houehanou, Corine; Msaidié, Mohamed; Guwatudde, David; Gurung, Mongal S; Gathecha, Gladwell; Dorobantu, Maria; Damasceno, Albertino; Bovet, Pascal; Bicaba, Brice W; Aryal, Krishna K; Andall-Brereton, Glennis; Andall-Brereton, Glennis; Agoudavi, Kokou; Stokes, Andrew; Davies, Justine I; Bärnighausen, Till; Atun, Rifat; Vollmer, Sebastian; Jaacks, Lindsay M (Elsevier, 2019-07-18)
    Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process ...
  • Status epilepticus enhances depotentiation after fully established LTP in an NMDAR-Dependent but GluN2B-independent manner 
    Guli, Xiati; Tokay, Tursonjan; Kirschstein, Timo; Köhling, Rüdiger (Neural Plasticity, 2015-11-15)
    N-Methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) can be reversed by low-frequency stimulation (LFS) referred to as depotentiation (DP). We previously found GluN2B upregulated in CA1 neurons from ...
  • The study of phenolic compounds of the berries of three species of plants of the genus vaccin-ium, growing in the khanty-mansi autonomous area 
    Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Гуляев, Александр; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории Сургутского ...
  • Synthesis of trans-porphyrin dimers for nonlinear optics 
    Baptayev, Bakhytzhan; Tauanov, Zhandos; Bissengaliyeva, Moldir; Zhakiyeva, Zhanar; Berillo, Dmitriy; Adilov, Salimgerey (“NURIS”, Nazarbayev University, Astana, Kazakhstan, 2014)
    Following the development of the idea of octupolar molecules as nonlinear optical materials a variety of compounds have been reported. Trans-porphyrins have a great potential to self-order into octupolar symmetry. Nonlinear ...
  • The role of infectious agents in urogenital cancers 
    Alibek, Kenneth; Karatayeva, Nargis; Bekniyazov, Ildar (BioMed Central, 2012-12-03)
    Since the late 1990s, infectious agents have been thought to play a role in the pathogenesis of approximately 15% of cancers. It is now widely accepted that infection of stomach tissue with the bacteria Helicobacter pylori ...
  • The universal non-neuronal nature of parkinson's disease: a theory 
    Valente, André; Adilbayeva, Altynai; Tokay, Tursonjan; Rizvanov, Albert A. (PeerJ PrePrints, 2015-08-19)
    Various recent developments of relevance to Parkinson's disease (PD) are discussed and integrated into a comprehensive hypothesis on the nature, origin and inter-cellular mode of propagation of late-onset sporadic PD. We ...
  • Thyroid abnormality trend over time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: a case review of pathological findings for 7271 patients 
    Zhumadilov, Zhaxybay; GUSEV, BORIS I.; TAKADA, JUN; HOSHI, Masaharu; Kimura, AKIRO; Hayakawa, Norihiko; Takeichi, Nobuo (Journal of Radiation Research, 2000)
    From 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and ...
  • Tooth enamel EPR dosimetry: optimization of EPR spectra recording parameters and effect of sample mass on spectral sensitivity 
    Zhumadilov, Kassym; Ivannikov, Alexander; Skvortsov, Valeriy; Stepanenko, Valeriy; Zhumadilov, Zhaxybay; Endo, Satoru; Tanaka, Kenichi; Hoshi, Masaharu (Journal of Radiation Research. http://jrr.jstage.jst.go.jp, 2005)
    conditions were optimized. The uncertainty of dose determination was obtained as the mean square deviation of doses, determined with the use of a spectra deconvolution program, from the nominal doses for ten enamel samples ...
  • Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution 
    Kairov, Ulykbek; Aynaud, Marie-Ming; Mirabeau, Olivier; Gruel, Nadege; Grossetête, Sandrine; Boeva, Valentina; Durand, Simon; Surdez, Didier; Zaïdi, Sakina; Gribkova, Svetlana; Fouché, Aziz; Raynal, Virginie; Tirode, Franck; Grünewald, Thomas G P; Bohec, Mylene; Baulande, Sylvain; Janoueix-Lerosey, Isabelle; Vert, Jean-Philippe; Barillot, Emmanuel (Cell Press, 2020-02-11)
    EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the ...
  • Transplantation of the fetal nerve cells in early post-reanimation period in rats 
    Tazhibaeva, D.; Olzhayev, F.; Kabdualieva, N.; Aitbaeva, Zh.; Zaripova, L. (Center for Life Sciences, Nazarbayev University, 2014)
    Cell technologies are widely used in medical practice these days. In this research we evaluated the effect of the fetal nerve cell transplantation on the rat survival after the case of clinical death from the mechanical asphyxia.
  • TRENDS OF COLORECTAL CANCER PREVALENCE IN KAZAKHSTAN RELATED TO SCREENING 
    Zhylkaidarova, Alma; Kaidarova, Dilyara; Batyrbekov, Kanat; Shatkovskaya, Oxana; Begimbetova, Dinara (Clinical Endoscopy, 2020-05)
    Colorectal cancer (CRC) is one of the global health problems and is the third leading cause of morbidity and second leading cause of mortality from cancer worldwide [1,2]. In the United States and European countries, the ...
  • Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data 
    Terlikbayeva, Assel; Hermosilla, Sabrina; Galea, Sandro; Schluger, Neil; Yegeubayeva, Saltanat; Abildayev, Tleukhan; Muminov, Talgat; Akiyanova, Farida; Bartkowiak, Laura; Zhumadilov, Zhaxybay; Sharman, Almaz; El-Bassel, Nabila (BMC Infectious Diseases. http://www.biomedcentral.com/1471-2334/12/262, 2012)
    Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well ...
  • Visualization of Bonghan Microcells by Electron and Atomic Force Microscopy 
    Baik, Ku Youn; Ogay, Vyacheslav; Jeoung, Sae Chae; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-04-13)
    Objectives: The origin of adult stem cells remains an open question. If they derive from embryos, it is difficult to determine the mechanism which interrupts their differentiation during tissue formation. In the 1960s, ...