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Browsing Center for Life Sciences by Title

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  • Zhurko, S.; Olzhayev, F.; Chiginev, V.; Fedorov, S. (Personalized medicine and Global Health, 2015)
    To conduct a clinical study of immediate results, assessment of hemodynamic characteristics of developed a new biological stented prosthesis «UniLine» (Russia, Kemerovo) designed for correction of heart valve lesions of ...
  • Umbayev, Bauyrzhan; Askarova, Sholpan; Almabayeva, Aigul; Saliev, Timur; Masoud, Abdul-Razak; Bulanin, Denis (Hindawi, 2020-06-17)
    Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable of damaging the skin’s vital components through nonenzymatic glycation, ...
  • Gritsenko, Dilyara; Pozharsky, Aleksandr; Deryabina, Nina; Kassenova, Aliya; Galiakparov, Nurbol (Genetika-Belgrade, 2019)
    The influenza is one of the most dangerous and widespread infectious diseases on the planet. A natural reservoir of the influenza A virus is wild waterfowl, which subsequently contribute to the spread of viral infection ...
  • Jeong, Choongwon; Balanovsky, Oleg; Lukianova, Elena; Kahbatkyzy, Nurzhibek; Flegontov, Pavel; Zaporozhchenko, Valery; Immell, Alexander; Wang, Chuan-Chao; Ixan, Olzhas; Khussainova, Elmira; Bekmanov, Bakhytzhan; Zaibert, Victor; Lavryashina, Maria; Pocheshkhova, Elvira; Yusupov, Yuldash; Agdzhoyan, Anastasiya; Koshel, Sergey; Bukin, Andrei; Nymadawa, Pagbajabyn; Turdikulova, Shahlo; Dalimova, Dilbar; Churnosov, Mikhail; Skhalyakho, Roza; Daragan, Denis; Bogunov, Yuri; Bogunova, Anna; Shtrunov, Alexandr; Dubova, Nadezhda; Zhabagin, Maxat; Yepiskoposyan, Levon; Churakov, Vladimir; Pislegin, Nikolay; Damba, Larissa; Saroyants, Ludmila; Dibirova, Khadizhat; Atramentova, Lubov; Utevska, Olga; Idrisov, Eldar; Kamenshchikova, Evgeniya; Evseeva, Irina; Metspalu, Mait; Outram, Alan K.; Robbeets, Martine; Djansugurova, Leyla; Balanovska, Elena; Schiffels, Stephan; Haak, Wolfgang; Reich, David; Krause, Johannes (Nature Ecology & Evolution, 2019-04)
    The indigenous populations of inner Eurasia-a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures and languages. In ...
  • Kozhakhmetov, Samat S.; Babenko, Dmitriy; Kozhakhmetova, Saniya; Tuyakova, Altynay; Nurgaziyev, Madiyar; Nurgozhina, Ayaulym; Muhanbetganov, Nurislam; Chulenbayeva, Laura; Sergazy, Shynggys; Gulyayev, Alexander; Tanabayev, Baimakhan; Saliev, Timur; Kushugulova, Almagul R. (Elsevier Ltd, 2021-06-08)
    Inflammatory bowel disease is one of the serious burdens of clinical medicine and healthcare. This study investigated the potential of a biological product based on mare's milk and metabolites of symbiotic microflora for ...
  • Pichugin, Vladimir; Melnikov, Nikolay; Olzhayev, F.; Medvedev, Alexander; Jourko, Sergey; Gamzaev, Alishir; Chiginev, Vladimir (Central Asian Journal of Global Health, 2014)
    Cardioplegic cardiac arrest with subsequent ischemic-reperfusion injuries can lead to the development of inflammation of the myocardium, leucocyte activation, and release of cardiac enzymes. Flow reduction to the bronchial ...
  • Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K. (Nature Research, 2017)
    Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...
  • Askarova, Sholpan; Yang, Xiaoguang; Lee, James C-M. (SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease, 2011-01-21)
    An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact ...
  • Klatte, Katharina; Kirschstein, Timo; Otte, David; Pothmann, Leonie; Muller, Lorenz; Tokay, Tursonjan; Kober, Maria; Uebachs, Mischa; Zimmer, Andreas; Beck, Heinz (Neurobiology of Disease, 2013-08-07)
    The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory ...
  • Ogay, Vyacheslav; Kumasheva, Venera; Li, Yelena; Mukhlis, Sholpan; Sekenova, Aliya; Olzhayev, Farkhad; Tsoy, Andrey; Umbayev, Baurzhan; Askarova, Sholpan; Shpekov, Azat; Kaliyev, Assylbek; Zhetpisbayev, Berik; Makhambetov, Yerbol; Akshulakov, Serik; Saparov, Arman; Ramankulov, Yerlan (SAGE Publications, 2020-09-04)
    Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation ...
  • Matkarimov, Bakhyt T.; Matta, Elie; Kiribayeva, Assel; Khassenov, Bekbolat; Ishchenko, Alexander A. (Springer Nature, 2020-02-28)
    DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise ...
  • Kulyyassov, Arman; Kalendar, Ruslan (MDPI, 2020-11-29)
    High-throughput sequencing technologies have greatly accelerated the progress of genomics, transcriptomics, and metagenomics. Currently, a large amount of genomic data from various organisms is being generated, the volume ...
  • Мусин, Е.А.; Jeffries, R.G.; Олжаев, Ф.С.; Исаева, Р.Б.; Жумадилов, Ж.Ш.; Салиев, Т.М.; Federspiel, W.J. (Национальное общество регенеративной медицины, 2015)
    Экспериментальная оценка возможности применения системы Hemolung в педиатрической практике.
  • Supiyev, Adil; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Sharman, Almaz; Marmot, Michael; Bobak, Martin (BioMed Central Public Health. http://www.biomedcentral.com/1471-2458/14/768, 2014)
    The high and fluctuating mortality and rising health inequalities in post-Soviet countries have attracted considerable attention. However, there are very few individual-level data on distribution of health outcomes in ...
  • Askarova, Sholpan; Umbayev, Bauyrzhan; Masoud, Abdul-Razak; Kaiyrlykyzy, Aiym; Safarova, Yuliya; Tsoy, Andrey; Olzhayev, Farkhad; Kushugulova, Almagul R. (Frontiers Media, 2020-03-18)
    Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence ...
  • Mao, Xiao-Yuan; Tokay, Tursonjan; Zhou, Hong-Hao; Jin, Wei-Lin (Oncotarget, 2016-03-07)
    Epileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of ...
  • Yang, Xiaoguang; Askarova, Sholpan; Sheng, Wenwen; Chen, JK; Sun, Albert Y.; Sun, Grace Y.; Yao, Gang; Leea, James C-M. (US National Library of Medicine National Institutes of Health, 2010-09-25)
    Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, ...
  • Belyayev, Alexander; Jandova, Michaela; Josefiova, Jiřina; Kalendar, Ruslan; Mahelka, Va´clav; Manda´k, Bohumil; Krak, Karol (Public Library of Science, 2020-10-27)
    Satellite DNA (satDNA) is one of the major fractions of the eukaryotic nuclear genome. Highly variable satDNA is involved in various genome functions, and a clear link between satellites and phenotypes exists in a wide ...
  • Yang, Xiaoguang; Askarova, Sholpan; Lee, James C-M. (Mol Neurobiol, 2010-05-01)
    Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. ...