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Browsing Center for Life Sciences by Title

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  • Determining the optimal number of independent components for reproducible transcriptomic data analysis 
    Kairov, Ulykbek; Cantini, Laura; Greco, Alessandro; Molkenov, Askhat; Czerwinska, Urszula; Barillot, Emmanuel; Zinovyev, Andrei (BioMed Central, 2017)
    Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the ...
  • Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan 
    Supiyev, Adil; Kossumov, Alibek; Kassenova, Aliya; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Peasey, Anne; Bobak, Martin (Diabetes Research and Clinical Practice, 2016-02-01)
    Abstract AimsThe evidence on the prevalence and distribution of diabetes and its determinants in Central Asia is sparse. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of ...
  • DNA-HISTONE CROSS-LINKS: FORMATION AND REPAIR 
    Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • Draft genome sequence of Lactobacillus rhamnosus CLS17 
    Zhumadilov, Zhaxybay; Kozhakhmetov, Samat S.; Kushugulova, Almagul R.; Saduakhasova, Saule A.; Shakhabayeva, Gulnara S.; Khassenbekova, Zhanagul R.; Molkenov, Askhat B.; Kairov, Ulykbek E.; Issayeva, Raushan B.; Nurgozhin, Talgat S. (Genome Announc, 2015)
    The human gut microbiome is an organ that provides primary barrier protection against foreign agents. Most of the microorganisms are different strains of commensal bacteria that are colonized in the gut. Gut flora influence ...
  • Draft genome sequences of two clinical Isolates of mycobacterium tuberculosis from sputum of Kazakh patients 
    Kairov, Ulykbek E.; Kozhamkulov, Ulan; Molkenov, Askhat; Rakhimova, Saule; Askapuli, Ayken; Zhabagin, Maxat; Akhmetova, Ainur; Yerezhepov, Dauren; Abilova, Zhannur; Abilmazhinova, Aliya; Bismilda, Venera; Chingisova, Leila; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (Genome Announc, 2015)
    Here, we report the draft genome sequences of two clinical isolates of Mycobacterium tuberculosis (MTB-476 and MTB-489) isolated from sputum of Kazakh patients.
  • DYNAMIC CHANGES IN MICROBIOME COMPOSITION FOLLOWING MARE’S MILK INTAKE FOR PREVENTION OF COLLATERAL ANTIBIOTIC EFFECT 
    Kushugulova, Almagul R.; Löber, Ulrike; Akpanova, Saniya; Rysbekov, Kairat; Kozhakhmetov, Samat S.; Khassenbekova, Zhanagul R.; Essex, Morgan; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Babenko, Dmitriy; Marko, Lajos; Forslund, Sofia K. (Frontiers Media S.A., 2021-04-21)
    Introduction: Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High antibiotic usage is especially common in children with developing microbiome. We hypothesized ...
  • Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System 
    Han, Bo; Tokay, Tursonjan; Zhang, Guangming; Sun, Peng; Hou, Shangwei (Oxidative Medicine and Cellular Longevity, 2017-03-06)
    Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the ...
  • Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis 
    Catanzaro, R.; Zerbinati, N.; Solimene, U.; Celep, G.; Marotta, F.; Kushugulova, A.; Milazzo, M.; Tomella, C.; Bertuccelli, G.; Zhumadilov, Z. (Drug Discoveries & Therapeutics. DOI: 10.5582/ddt.2013.v7.5.196, 2013)
    The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in ...
  • Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue 
    González-Plaza, Juan José; Gutiérrez-Repiso, Carolina; García-Serrano, Sara; Rodriguez-Pacheco, Francisca; Garrido-Sánchez, Lourdes; Santiago-Fernández, Concepción; García-Arnés, Juan; Moreno-Ruiz, Francisco J.; Rodríguez-Cañete, Alberto; García-Fuentes, Eduardo (Surgery for Obesity and Related Diseases, 2016-02-01)
    Abstract BackgroundThe changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown. ObjectivesTo investigate ...
  • Effects of amyloid beta peptide on neurovascular cells 
    Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)
    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
  • Efficiency of screening colonoscopy for diagnosis of precancerous and canserous disease of digestive tract 
    Batyrbekov, K.; Olzhayev, F.; Shanazarov, N.; Maschkin, A. (Personalized medicine and Global Health, 2015)
    Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. According to World Gastroenterology Organization CRC is the second leading cause of cancer deaths among men and women that makes more than ...
  • Electrical сharacterization of proposed transpositional acupoints on the Urinary Bladder Meridian in a Rat Model 
    Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup; Myoung, Hyoun-Seok; Lee, Kyoung-Joung; Ogay, Vyacheslav; Lee, Yong-Heum (Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine., 2011)
    Specific electrical characteristicsof acupointswere investigated on the urinary bladder (BL) meridian in 14 rats. BL acupointsand non-acupoints on the back were selected and their electrical voltages were measured by using ...
  • Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis 
    Kaiyrlykyzy, Aiym; Freese, Kyle E.; Elishaev, Esther; Bovbjerg, Dana H.; Ramanathan, Ramesh; Hamad, Giselle G.; McCloskey, Carol; Althouse, Andrew D.; Huang, Marilyn; Edwards, Robert P.; Linkov, Faina (Surgery for Obesity and Related Diseases, 2015-05-01)
    Abstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study ...
  • Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis 
    Kaiyrlykyzy, Aiym; Freese, Kyle E.; Elishaev, Esther; Bovbjerg, Dana H.; Ramanathan, Ramesh; Hamad, Giselle G.; McCloskey, Carol; Althouse, Andrew D.; Huang, Marilyn; Edwards, Robert P.; Linkov, Faina (2015-05-01)
    Abstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study ...
  • Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting 
    D'Souza, Sonia; Murata, Hironobu; Jose, Moncy V.; Askarova, Sholpan; Yantsen, Yuliya; Andersen, Jill D.; Edington, Collin D.J.; Clafshenkel, William P.; Koepsel, Richard R.; Russell, Alan J. (Biomaterials, 2014-11-01)
    Abstract The field of polymer-based membrane engineering has expanded since we first demonstrated the reaction of N-hydroxysuccinimide ester-terminated polymers with cells and tissues almost two decades ago. One remaining ...
  • ESR dosimetry study of population in the vicinity of the Semipalatinsk Nuclear Test Site 
    Zhumadilov, Kassym; Ivannikov, Alexander; Stepanenko, Valeriy; Zharlyganova, Dinara; Toyoda, Shin; Zhumadilov, Zhaxybay; Hoshi, Masaharu (Journal of Radiation Research. doi: 10.1093/jrr/rrt008, 2013-02)
    A tooth enamel electron spin resonance (ESR) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the Semipalatinsk region of Kazakhstan, ...
  • Evaluation of amino acid level in the blood of fetuses and newborns with intrauterine growth restriction 
    Chuvakova, T.; Bapayeva, G.; Issayeva, R.; Olzhayev, F.; Dzhamanaeva, K.; Kenbaeva, K. (Personalized medicine and Global Health, 2015)
    The processes of growth of the fetus are provided by a constant supply of amino acids from mother, which provides the production of proteins and muscle tissue of the fetus. The purpose of this research was to study the ...
  • EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICE/ ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ 
    Mussin (Мусин), Y.A. (Е.А.); Bulanin (Буланин), D.S. (Д.С.); Jeffries (Джеффрис), R.G. (Р.Дж.); Zhumadilov (Жумадилов), Zhaxybay (Ж.Ш.); Olzhayev, F.; Federspiel (Федерспил), W.J. (В.Дж.) (ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ, том XVI, № 4, 2014)
    Основной целью данной работы является получение первичных данных о нагнетательной способности гемопомпы устройства Hemolung и способности обеспечить адекватный уровень газообмена при использовании катетеров уменьшенного ...
  • Evaluation of health outcomes and cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccination for infants in Kazakhstan 
    Bektur, C.R.; Nurgozhin, T.S. (Clinical Therapeutics, 2015-08-01)
  • First experience of using biological prosthesis "UniLine" for correction of heart valve diseases 
    Zhurko, S.; Olzhayev, F.; Chiginev, V.; Fedorov, S. (Personalized medicine and Global Health, 2015)
    To conduct a clinical study of immediate results, assessment of hemodynamic characteristics of developed a new biological stented prosthesis «UniLine» (Russia, Kemerovo) designed for correction of heart valve lesions of ...