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Browsing Center for Life Sciences by Issue Date

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  • The study of phenolic compounds of the berries of three species of plants of the genus vaccin-ium, growing in the khanty-mansi autonomous area 
    Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Гуляев, Александр; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории Сургутского ...
  • Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution 
    Kairov, Ulykbek; Aynaud, Marie-Ming; Mirabeau, Olivier; Gruel, Nadege; Grossetête, Sandrine; Boeva, Valentina; Durand, Simon; Surdez, Didier; Zaïdi, Sakina; Gribkova, Svetlana; Fouché, Aziz; Raynal, Virginie; Tirode, Franck; Grünewald, Thomas G P; Bohec, Mylene; Baulande, Sylvain; Janoueix-Lerosey, Isabelle; Vert, Jean-Philippe; Barillot, Emmanuel (Cell Press, 2020-02-11)
    EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the ...
  • Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation 
    Matkarimov, Bakhyt T.; Matta, Elie; Kiribayeva, Assel; Khassenov, Bekbolat; Ishchenko, Alexander A. (Springer Nature, 2020-02-28)
    DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise ...
  • ИЗУЧЕНИЕ ФЕНОЛЬНЫХ СОЕДИНЕНИЙ ЯГОД ТРЕХ ВИДОВ РАСТЕНИЙ РОДА VACCINIUM, ПРОИЗРАСТАЮЩИХ В ХАНТЫМАНСИЙСКОМ АВТОНОМНОМ ОКРУГЕ 
    Gulyayev, Alexandr; Гуляев, Александр; Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020-03-05)
    Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории ...
  • The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease 
    Askarova, Sholpan; Umbayev, Bauyrzhan; Masoud, Abdul-Razak; Kaiyrlykyzy, Aiym; Safarova, Yuliya; Tsoy, Andrey; Olzhayev, Farkhad; Kushugulova, Almagul R. (Frontiers Media, 2020-03-18)
    Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence ...
  • Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration 
    Safarova, Yuliya; Umbayev, Bauyrzhan; Hortelano, Gonzalo; Askarova, Sholpan (Future Medicine, 2020-04-16)
    In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal ...
  • TRENDS OF COLORECTAL CANCER PREVALENCE IN KAZAKHSTAN RELATED TO SCREENING 
    Zhylkaidarova, Alma; Kaidarova, Dilyara; Batyrbekov, Kanat; Shatkovskaya, Oxana; Begimbetova, Dinara (Clinical Endoscopy, 2020-05)
    Colorectal cancer (CRC) is one of the global health problems and is the third leading cause of morbidity and second leading cause of mortality from cancer worldwide [1,2]. In the United States and European countries, the ...
  • GALACTOSE-INDUCED SKIN AGING: THE ROLE OF OXIDATIVE STRESS 
    Umbayev, Bauyrzhan; Askarova, Sholpan; Almabayeva, Aigul; Saliev, Timur; Masoud, Abdul-Razak; Bulanin, Denis (Hindawi, 2020-06-17)
    Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable of damaging the skin’s vital components through nonenzymatic glycation, ...
  • IMPROVEMENT OF NEUROLOGICAL FUNCTION IN RATS WITH ISCHEMIC STROKE BY ADIPOSEDERIVED PERICYTES 
    Ogay, Vyacheslav; Kumasheva, Venera; Li, Yelena; Mukhlis, Sholpan; Sekenova, Aliya; Olzhayev, Farkhad; Tsoy, Andrey; Umbayev, Baurzhan; Askarova, Sholpan; Shpekov, Azat; Kaliyev, Assylbek; Zhetpisbayev, Berik; Makhambetov, Yerbol; Akshulakov, Serik; Saparov, Arman; Ramankulov, Yerlan (SAGE Publications, 2020-09-04)
    Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation ...
  • MESENCHYMAL STEM CELLS COATED WITH SYNTHETIC BONE-TARGETING POLYMERS ENHANCE OSTEOPOROTIC BONE FRACTURE REGENERATION 
    Safarova, Yuliya; Olzhayev, Farkhad; Umbayev, Bauyrzhan; Tsoy, Andrey; Hortelano, Gonzalo; Tokay, Tursonjan; Murata, Hironobu; Russell, Alan; Askarova, Sholpan (MDPI AG, 2020-10-12)
    Osteoporosis is a progressive skeletal disease characterized by reduced bone density leading to bone fragility and an elevated risk of bone fractures. In osteoporotic conditions, decrease in bone density happens due to the ...
  • THE MAJOR SATELLITE DNA FAMILIES OF THE DIPLOID CHENOPODIUM ALBUM AGGREGATE SPECIES: ARGUMENTS FOR AND AGAINST THE “LIBRARY HYPOTHESIS” 
    Belyayev, Alexander; Jandova, Michaela; Josefiova, Jiřina; Kalendar, Ruslan; Mahelka, Va´clav; Manda´k, Bohumil; Krak, Karol (Public Library of Science, 2020-10-27)
    Satellite DNA (satDNA) is one of the major fractions of the eukaryotic nuclear genome. Highly variable satDNA is involved in various genome functions, and a clear link between satellites and phenotypes exists in a wide ...
  • A NEW INSIGHT ON THE RADIOPROTECTIVE POTENTIAL OF EPSILON-AMINOCAPROIC ACID 
    Takagi, Satoshi; Oyama, Takuto; Jimi, Shiro; Saparov, Arman; Ohjimi, Hiroyuki (MDPI, 2020-11-25)
    Negative pressure wound therapy (NPWT) has been commonly used over the years for a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is recently becoming a powerful modality for ...
  • THE ARABIDOPSIS THALIANA POLY(ADP-RIBOSE) POLYMERASES 1 AND 2 MODIFY DNA BY ADP-RIBOSYLATING TERMINAL PHOSPHATE RESIDUES 
    Taipakova, Sabira; Kuanbay, Aigerim; Saint-Pierre, Christine; Gasparutto, Didier; Baiken, Yeldar; Groisman, Regina; Ishchenko, Alexander A.; Saparbaev, Murat; Bissenbaev, Amangeldy K. (Frontiers Media, 2020-11-26)
    Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor ...
  • IN SILICO ESTIMATION OF THE ABUNDANCE AND PHYLOGENETIC SIGNIFICANCE OF THE COMPOSITE OCT4-SOX2 BINDING MOTIFS WITHIN A WIDE RANGE OF SPECIES 
    Kulyyassov, Arman; Kalendar, Ruslan (MDPI, 2020-11-29)
    High-throughput sequencing technologies have greatly accelerated the progress of genomics, transcriptomics, and metagenomics. Currently, a large amount of genomic data from various organisms is being generated, the volume ...
  • WHOLE GENOME SEQUENCE DATA OF MYCOBACTERIUM TUBERCULOSIS XDR STRAIN, ISOLATED FROM PATIENT IN KAZAKHSTAN 
    Daniyarov, Asset; Molkenov, Askhat; Rakhimova, Saule; Akhmetova, Ainur; Nurkina, Zhannur; Yerezhepov, Dauren; Chingissova, Lyailya; Bismilda, Venera; Toxanbaeva, Bekzat; Akilzhanova, Ainur; Kozhamkulov, Ulan; Kairov, Ulykbek (Elsevier, 2020-12)
    Drug-resistant tuberculosis (TB) is a major public health problem. Clinical Mycobacterium tuberculosis (MTB) isolate with Extensively drug-resistant tuberculosis (MTB-XDR) profile was subjected to whole-genome sequencing ...
  • DNA-HISTONE CROSS-LINKS: FORMATION AND REPAIR 
    Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • WHOLE-GENOME SEQUENCING DATA OF KAZAKH INDIVIDUALS 
    Kairov, Ulykbek; Molkenov, Askhat; Rakhimova, Saule; Kozhamkulov, Ulan; Sharip, Aigul; Karabayev, Daniyar; Daniyarov, Asset; Lee, Joseph H.; Terwilliger, Joseph D.; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (BioMed Central Ltd, 2021-02-04)
    Objectives: Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today ...
  • ANALYSIS OF BACTEROIDES FRAGILIS CLINICAL STRAINS ISOLATED IN KAZAKHSTAN 
    Zholdybayeva, Elena V.; Kozhahmetova, Saniya; Tarlykov, Pavel; Atavliyeva, Sabina; Mukhtarova, Kymbat; Syzdykov, Tleuli; Khasenov, Ruslan; Shevtsov, Alexsandr; Amirgazin, Asylulan; Daniyarov, Asset; Ramankulov, Yerlan (Microbiology Resource Announcements, 2021-02-04)
    Our aim was to study the nucleotide sequences of 9 previously undescribed strains of B. fragilis collected from patients with intra-abdominal diseases at city hospitals in Nur-Sultan, Kazakhstan.
  • DYNAMIC CHANGES IN MICROBIOME COMPOSITION FOLLOWING MARE’S MILK INTAKE FOR PREVENTION OF COLLATERAL ANTIBIOTIC EFFECT 
    Kushugulova, Almagul R.; Löber, Ulrike; Akpanova, Saniya; Rysbekov, Kairat; Kozhakhmetov, Samat S.; Khassenbekova, Zhanagul R.; Essex, Morgan; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Babenko, Dmitriy; Marko, Lajos; Forslund, Sofia K. (Frontiers Media S.A., 2021-04-21)
    Introduction: Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High antibiotic usage is especially common in children with developing microbiome. We hypothesized ...
  • RE-SEARCHER: GUI-BASED BIOINFORMATICS TOOL FOR SIMPLIFIED GENOMICS DATA MINING OF VCF FILES 
    Karabayev, Daniyar; Molkenov, Askhat; Yerulanuly, Kaiyrgali; Kabimoldayev, Ilyas; Daniyarov, Asset; Sharip, Aigul; Seisenova, Ainur; Zhumadilov, Zhaxybay; Kairov, Ulykbek (PeerJ Inc., 2021-05-03)
    Background. High-throughput sequencing platforms generate a massive amount of high-dimensional genomic datasets that are available for analysis. Modern and user-friendly bioinformatics tools for analysis and interpretation ...