NU Research Week - I

Permanent URI for this collection

https://testres.nu.edu.kz/handle/123456789/410

Browse

Browsing NU Research Week - I by Author "Adarichev, V. A."

Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Design and development of multivalent peptide vaccine candidate against influenza a virus
    (Nazarbayev University, 2013) Chinybayeva, A. K.; Kabdullina, A.; Soltabayeva, A.; Myngbay, A.; Adarichev, V. A.; Alibek, K.
    Influenza virus is a major pathogen with global spread which infects birds and mammals, including humans. The virus is constantly changing, thus influenza stays in the centre of vaccine research. Effective vaccine should have a wide spectrum of protection from the most circulating and dangerous subtypes of the virus. Our goals are identifying the most immunogenic peptide epitopes among three subtypes of Influenza A virus (H1N1, H3N2 и H5N1) according to affinity to MHC class I & II molecules, and finding epitopes localized in conservative regions of the viral proteome. We propose to screen synthetic oligopeptides emulating conservative and immunogenic regions for the strongest humoral and cell mediated responses in mice to select several epitopes/peptides as multivalent peptide vaccine candidate.
  • Thumbnail Image
    ItemOpen Access
    Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency
    (Nazarbayev University, 2013) Adarichev, V. A.; Sarkar, S.; Kalamov, N.; Brucker, J.; Forde, T. S.; Shekhani, M.T.; Lyons, B.
    We found that Pgis2-congenic mice that carry genetically-deficient copy of C5(Hc) complement component were susceptible to collagen antibody-induced arthritis while inflammation was transient. Using differential gene expression analysis tools, we identified 20 genes whose down/up regulation in Pgis2-congenic mice might rescue C5 complement deficiency or, in a wider sense, rescue the function of the entire Pgis2 locus.