Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency
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Date
2013
Authors
Adarichev, V. A.
Sarkar, S.
Kalamov, N.
Brucker, J.
Forde, T. S.
Shekhani, M.T.
Lyons, B.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
We found that Pgis2-congenic mice that carry genetically-deficient copy of C5(Hc) complement component were susceptible to collagen antibody-induced arthritis while inflammation was transient. Using differential gene expression analysis tools, we identified 20 genes whose down/up regulation in Pgis2-congenic mice might rescue C5 complement deficiency or, in a wider sense, rescue the function of the entire Pgis2 locus.
Description
Keywords
first research week, arthritis, science