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Browsing Abstracts by Author "Akhmetova, A."

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    A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan
    (2016-05) Akilzhanova, A.; Guelly, Ch.; Abilova, Zh.; Rakhimova, S.; Akhmetova, A.; Kairov, U.; Nuralinov, O.; Rashbayeva, G.; Trajanoski, S.; Zhumadilov, Zh.; Bebosynova, M.
    Ventricular tachycardia (VT) is a common symptom in cardiac disorders of different etiology. Abnormalities of ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function of channels, which can predispose to arrhythmias. Due to the high incidence of cardiovascular disorders in Kazakhstan, we enrolled a study cohort of 95 patients of different clinical phenotypes of cardiomyopathies, including DCM, idiopathic VT but also patients with myocardial infarction as a consequence of coronary heart disease. The common denominator among the three main groups was the occurrence of severe episodes of VT in all patients. Using targeted resequencing, we investigated 96 cardiomyopathy associated candidate-genes in this cohort with the aim to detect rare and common variations in these genes associated with VT molecular basis
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    Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage
    (2016-05) Khassenbekova, Zh.; Berikkhanova, K.; Gulyayev, A.; Sergazy, Sh.; Yermekbayeva, В.; Kushugulova, A.R.; Omarova, D.; Akhmetova, A.; Nurgozhin, T.; Zhumadilov, Zh.
    Correction of phenotypic plasticity of macrophages for reprogramming inflammatory response is of great interest to modern medicine. To date, there are lots of factors, which can alter macrophages' phenotype to M1 or M2. The introduction of drug containing autologous erythrocyte ghosts is one of such factors. We have developed a method for the targeted delivery of autologous erythrocyte ghosts loaded with antibiotic (pharmacocytes) directly into the wound tissues. Introduction of pharmacocytes to the purulent wound ensures high therapeutic concentrations of the antibiotic, which leads to rapid arresting of the phase of the inflammatory process and thus results in early healing. In order to explain this phenomenon, we investigated the effect of the pharmacocytes on the phenotypic polarization of macrophages.
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    Removal of low and middle molecular weight toxins by activated carbon materials
    (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05) Akhmetova, A.; Howell, C.; Jandosov, J.; Baimenov, A.; Mansurov, Z.; Nurgozhin, T.; Mikhalovsky, S.
    Haemoperfusion (HP), or blood purification via adsorption, has been introduced almost at the same time as haemodialysis in 1960s. HP compared to dialysis does not introduce any substances into the body and only removes the target molecules. Here, we research properties of activated carbon (AC) materials for HP purposes, which can efficiently adsorb substances in a broad range of molecular weights. Removing these substances individually, e.g., by selective antibodies is prohibitively expensive and inefficient due to their short life-time in blood circulation. And, dialysis and ultrafiltration are unable to remove these low and middle molecular weight (LMW, MMW) substances efficiently. Here, we assess adsorption of uremic toxins: p-cresyl sulfate, indoxyl sulfate, and urea.