Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage
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Date
2016-05
Authors
Khassenbekova, Zh.
Berikkhanova, K.
Gulyayev, A.
Sergazy, Sh.
Yermekbayeva, В.
Kushugulova, A.R.
Omarova, D.
Akhmetova, A.
Nurgozhin, T.
Zhumadilov, Zh.
Journal Title
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Abstract
Correction of phenotypic plasticity of macrophages for reprogramming inflammatory
response is of great interest to modern medicine. To date, there are lots of factors, which can
alter macrophages' phenotype to M1 or M2. The introduction of drug containing autologous
erythrocyte ghosts is one of such factors.
We have developed a method for the targeted delivery of autologous erythrocyte ghosts loaded
with antibiotic (pharmacocytes) directly into the wound tissues. Introduction of pharmacocytes
to the purulent wound ensures high therapeutic concentrations of the antibiotic, which leads to
rapid arresting of the phase of the inflammatory process and thus results in early healing.
In order to explain this phenomenon, we investigated the effect of the pharmacocytes on the
phenotypic polarization of macrophages.
Description
Keywords
phenotypic plasticity of macrophages
Citation
Khassenbekova Zh., Berikkhanova K., Gulyayev A., Sergazy Sh., Yermekbayeva В., Kushugulova A.R., Omarova D., Akhmetova A., Nurgozhin T., and Zhumadilov Zh. 2016. Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1523