Abstract:
The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the
induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission
in the hippocampus, and cognitive impairments in aged animals are accompanied by reduced NMDARmediated
plasticity at Schaffer collateral—CA1 synapses. However, the specific contribution of NMDAR
subunits to NMDAR-mediated synaptic responses in aged tissue has not yet been fully understood. The
main purpose of present study was to examine whether there is an impact of aging on NMDAR subunit
expression and whether synaptic plasticity may depend on NMDAR subunit composition in the aged
hippocampus.
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