Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats

dc.contributor.author	Tokay, T.
dc.contributor.author	Rehberg, M.
dc.contributor.author	Kirschstein, T.
dc.contributor.author	Rohde, M.
dc.contributor.author	Mueller, L.
dc.contributor.author	Askarova, Sholpan
dc.contributor.author	Kohling, R.
dc.contributor.author	Zhumadilov, Z.
dc.date.accessioned	2015-10-27T09:17:29Z
dc.date.available	2015-10-27T09:17:29Z
dc.date.issued	2014
dc.identifier.isbn	9786018046728
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/535
dc.description.abstract	The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission in the hippocampus, and cognitive impairments in aged animals are accompanied by reduced NMDARmediated plasticity at Schaffer collateral—CA1 synapses. However, the specific contribution of NMDAR subunits to NMDAR-mediated synaptic responses in aged tissue has not yet been fully understood. The main purpose of present study was to examine whether there is an impact of aging on NMDAR subunit expression and whether synaptic plasticity may depend on NMDAR subunit composition in the aged hippocampus.	ru_RU
dc.language.iso	en	ru_RU
dc.publisher	Nazarbayev University	ru_RU
dc.subject	hippocampus	ru_RU
dc.subject	aged animals	ru_RU
dc.subject	NR2B/NR2A ratio	ru_RU
dc.subject	synaptic plasticity	ru_RU
dc.title	Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats	ru_RU
dc.type	Abstract	ru_RU