INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE
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Mitidieri, Emma
Vellecco, Valentina
Brancaleone, Vincenzo
Vanacore, Domenico
Manzo, Onorina L.
Martin, Emil
Sharina, Iraida
Krutsenko, Yekaterina
Monti, Maria Chiara
Morretta, Elva
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British Journal of Pharmacology
Abstract
l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. Here, we have investigated the signalling involved in the H2S-induced contraction.
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Mitidieri, E., Vellecco, V., Brancaleone, V., Vanacore, D., Manzo, O. L., Martin, E., Sharina, I., Krutsenko, Y., Monti, M. C., Morretta, E., Papapetropoulos, A., Caliendo, G., Frecentese, F., Cirino, G., Sorrentino, R., d’Emmanuele Di Villa Bianca, R., & Bucci, M. (2021). Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone. British Journal of Pharmacology, 178(18), 3765–3782. https://doi.org/10.1111/bph.15516
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