INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE
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Date
2021-04-30
Authors
Mitidieri, Emma
Vellecco, Valentina
Brancaleone, Vincenzo
Vanacore, Domenico
Manzo, Onorina L.
Martin, Emil
Sharina, Iraida
Krutsenko, Yekaterina
Monti, Maria Chiara
Morretta, Elva
Journal Title
Journal ISSN
Volume Title
Publisher
British Journal of Pharmacology
Abstract
l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. Here, we have investigated the signalling involved in the H2S-induced contraction.
Description
Keywords
Type of access: Open Access, l-cysteine donors
Citation
Mitidieri, E., Vellecco, V., Brancaleone, V., Vanacore, D., Manzo, O. L., Martin, E., Sharina, I., Krutsenko, Y., Monti, M. C., Morretta, E., Papapetropoulos, A., Caliendo, G., Frecentese, F., Cirino, G., Sorrentino, R., d’Emmanuele Di Villa Bianca, R., & Bucci, M. (2021). Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone. British Journal of Pharmacology, 178(18), 3765–3782. https://doi.org/10.1111/bph.15516