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INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE

INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE

Mitidieri, Emma; Vellecco, Valentina; Brancaleone, Vincenzo; Vanacore, Domenico; Manzo, Onorina L.; Martin, Emil; Sharina, Iraida; Krutsenko, Yekaterina; Monti, Maria Chiara; Morretta, Elva; Papapetropoulos, Andreas; Caliendo, Giuseppe; Frecentese, Francesco; Cirino, Giuseppe; Sorrentino, Raffaella; Bianca, Roberta d'Emmanuele di Villa; Bucci, Mariarosaria
URI: http://nur.nu.edu.kz/handle/123456789/5828
Date: 2021-04-30

Abstract:

l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. Here, we have investigated the signalling involved in the H2S-induced contraction.

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