D-serine improves learning and memory in epileptic animals
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Tokay, T.
Mueller, L.
Xie, Y.
Kirschstein, T.
Beck, H.
Koehling, R.
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Abstract
The N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of
synaptic plasticity and is essential for many forms of learning and memory. Activation of NMDAR
by glutamate requires the presence of D-Serine, which is an endogenous physiological coagonist
of the receptor and plays an important role in glutamate mediated NMDAR-dependent
synaptic plasticity in the brain. However, the role of D-serine in synaptic plasticity and learning
in chronic epilepsy is not known.
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T. Tokay, L. Mueller, Y. Xie, T. Kirschstein, H. Beck, and R. Koehling. 2016. D-series improves learning and memory in epileptic animals. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1518
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