ROS MEDIATED THERANOSTIC MATERIALS
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Date
2023
Authors
Abilova, Ayaulym
Journal Title
Journal ISSN
Volume Title
Publisher
School of Engineering and Digital Sciences
Abstract
Image-guided therapy or theranostics is a promising emerging approach in drug delivery
systems that allows for overcoming severe side effects of conventional treatment options. Reactive
oxygen species (ROS) are essential players in normal cell functioning; however, their abnormal
metabolism is associated with numerous acute and chronic conditions. Therefore, the
overproduction of ROS may serve as an attractive biomarker for tracking the early progression of
the diseases. Herein, we studied ROS activatable nanoparticles comprising peroxyoxalate esters
capable of multimodal imaging and smart drug release, simultaneously, in the biomarker-rich
microenvironment. A fluorinated oxalate compound (FOC), chemiexcitation source, fluorophore,
or photosensitizer were co-encapsulated with Pluronic F-127 forming nanoparticles (NPs). Upon
perhydrolysis reaction with hydrogen peroxide - the most stable and abundant form of ROS,
oxidation of the FOC results in degradation of the hydrophobic matrix of the NPs, giving rise to
the chemiluminescence (CL) emission, the release of fluorinated alcohol acting as 19F MRI
contrasting agent and drug release, at the same time. Thus, the ROS-sensitive nanoprobe may
enable precise tracking of the inflamed tissues (cells undergoing excessive oxidative stress) via
multiple imaging modalities accompanied with biomarker-specific drug delivery
Description
Keywords
Type of access: Embargo, Reactive oxygen species, peroxyoxalate chemiluminescence, 19F NMR/MRI, drug delivery, bioimaging, theranostics
Citation
Abilova, A. (2023). Ros mediated theranostic materials. School of Engineering and Digital Sciences