PREVALENCE OF HIGH-RISK HUMAN PAPILLOMAVIRUS INFECTION AMONG KAZAKHSTANI WOMEN ATTENDING GYNECOLOGICAL OUTPATIENT CLINICS

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Date

2021-06-07

Authors

Babi, Aisha
Issa, Torgyn
Issanov, Alpamys
Akilzhanova, Ainur
Nurgaliyeva, Kadisha
Abugalieva, Zauresh
Ukybassova, Talshyn
Daribay, Zhanibek
Khan, Saleem A.
Chan, Chee Kai

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier B.V.

Abstract

Objectives: To conduct a nationwide high-risk human papillomavirus (HR-HPV) infection genotyping analysis of women attending gynecological clinics and identify factors associated with HR-HPV infection. Methods: A cross-sectional survey-based study with 759 participants. Demographics, lifestyle, and medical history data were collected by questionnaire completed by gynecologists during patients’ visits. Cervical swabs were used for HPV genotyping using AmpliSens kit. Data analysis included descriptive statistics consisting of mean values, standard deviations, and frequencies, where applicable. Ordinal logistic regression was performed to identify factors associated with HPV infection status. Results: The mean age of participants was 36.51 ± 10.09 years. The majority of participants were aged 26–35 years. Less than half of the women (39%) were HPV positive; 26% had single HR-HPV, and 13% had multiple HR-HPV infection. The most prevalent HR-HPV genotypes were HPV-16 (54%), HPV-51 (7%), HPV-68 (7%), and HPV-18 (6%). Ordinal logistic regression demonstrated that older age, not being single, and having a history of sexually transmitted infections, decrease the odds of HPV infection. Conclusion: This study identified high prevalence of HR-HPV among Kazakhstani women. Our results showed that adding HPV testing to compulsory cervical cancer screening in Kazakhstan could improve the screening program and decrease cervical cancer rates.

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Keywords

Type of access: Open Access, Research Subject Categories::MEDICINE, Cervical cancer, Cervical intraepithelial neoplasia, High-risk HPV, HPV, HPV epidemiology, Kazakhstan

Citation

Babi, A., Issa, T., Issanov, A., Akilzhanova, A., Nurgaliyeva, K., Abugalieva, Z., Ukybassova, T., Daribay, Z., Khan, S. A., Chan, C. K., Azizan, A., & Aimagambetova, G. (2021). Prevalence of high-risk human papillomavirus infection among Kazakhstani women attending gynecological outpatient clinics. International Journal of Infectious Diseases, 109, 8–16. https://doi.org/10.1016/j.ijid.2021.06.006

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