REVIEW: DETECTION AND QUANTIFICATION OF PROTEINS IN HUMAN URINE
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Date
2021
Authors
Aitekenov, Sultan
Gaipov, Abduzhappar
Bukasov, Rostislav
Journal Title
Journal ISSN
Volume Title
Publisher
Talanta
Abstract
Extensive medical research showed that patients, with high protein concentration in urine, have various kinds of kidney diseases, referred to as proteinuria. Urinary protein biomarkers are useful for diagnosis of many health conditions – kidney and cardio vascular diseases, cancers, diabetes, infections. This review focuses on the
instrumental quantification (electrophoresis, chromatography, immunoassays, mass spectrometry, fluorescence spectroscopy, the infrared spectroscopy, and Raman spectroscopy) of proteins (the most of all albumin) in human
urine matrix. Different techniques provide unique information on what constituents of the urine are. Due to complex nature of urine, a separation step by electrophoresis or chromatography are often used for proteomics study of urine.
Description
Keywords
Urine proteomics, Biomarkers, Human serum albumin, Immunoassays, Mass spectrometry, Fluorescence spectroscopy
Citation
Aitekenov, S., Gaipov, A., & Bukasov, R. (2021). Review: Detection and quantification of proteins in human urine. Talanta, 223(Pt 1), 121718. https://doi.org/10.1016/j.talanta.2020.121718