Genetic homongeneity and major histocompatibility complex haplotyping of white mice
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Date
2014
Authors
Sydykova, K.
Sadykov, M.
Zhailauova, A.
Adilbayeva, A.
Myngbay, A.
Adarichev, V. A.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
Inbred murine strains are generated to insure genetic homogeneity and uniqueness
and define immune characteristics, like major histocompatibility complex (MHC) haplotype, of the
experimental model. Maintaining of the perfect inbred stock leads to increased level of homozygosity
and sometimes encounters a problem of inbreeding depression and consequently deviation from
strict inbreeding protocol. Our goals are (i) study genetic homogeneity of mice in the colony, and (ii)
haplotyping of H-2 complex (MHC in mice) in this strain.
Description
Keywords
genetic homogeneity, histocompatibility complex, haplotype, DNA product