PROGRESS AND PROSPECTS OF POLYMER-BASED DRUG DELIVERY SYSTEMS FOR BONE TISSUE REGENERATION

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dc.contributor.authorOgay, Vyacheslav
dc.contributor.authorMun, Ellina A.
dc.contributor.authorKudaibergen, Gulshakhar
dc.contributor.authorBaidarbekov, Murat
dc.contributor.authorKassymbek, Kuat
dc.contributor.authorZharkinbekov, Zharylkasyn
dc.contributor.authorSaparov, Arman
dc.date.accessioned2021-01-27T06:00:47Z
dc.date.available2021-01-27T06:00:47Z
dc.date.issued2020-12-01
dc.description.abstract: Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.en_US
dc.identifier.citationOgay, V., Mun, E. A., Kudaibergen, G., Baidarbekov, M., Kassymbek, K., Zharkinbekov, Z., & Saparov, A. (2020). Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration. Polymers, 12(12), 2881. https://doi.org/10.3390/polym12122881en_US
dc.identifier.issn2073-4360
dc.identifier.urihttps://www.mdpi.com/2073-4360/12/12/2881
dc.identifier.urihttps://doi.org/10.3390/polym12122881
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5248
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesPolymers;2020, 12(12), 2881
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectpolymeren_US
dc.subjectnanoparticleen_US
dc.subjectmicroparticleen_US
dc.subjectdrug delivery systemen_US
dc.subjectbone tissue regenerationen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistryen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCESen_US
dc.titlePROGRESS AND PROSPECTS OF POLYMER-BASED DRUG DELIVERY SYSTEMS FOR BONE TISSUE REGENERATIONen_US
dc.typeArticleen_US
workflow.import.sourcescience

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