PROGRESS AND PROSPECTS OF POLYMER-BASED DRUG DELIVERY SYSTEMS FOR BONE TISSUE REGENERATION
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Date
2020-12-01
Authors
Ogay, Vyacheslav
Mun, Ellina A.
Kudaibergen, Gulshakhar
Baidarbekov, Murat
Kassymbek, Kuat
Zharkinbekov, Zharylkasyn
Saparov, Arman
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
: Despite the high regenerative capacity of bone tissue, there are some cases where bone
repair is insufficient for a complete functional and structural recovery after damage. Current surgical
techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded
with drugs. However, there are certain disadvantages associated with these techniques in clinical
usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery
systems based on biodegradable natural and synthetic polymers were developed and examined in
in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play
a key role in the development of innovative drug delivery systems and tissue engineered constructs,
which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss
the most recent advances in the field of polymer-based drug delivery systems for the promotion of
bone tissue regeneration and the physical-chemical modifications of polymers for controlled and
sustained release of one or more drugs. In addition, special attention is given to recent developments
on polymer nano- and microparticle-based drug delivery systems for bone regeneration.
Description
Keywords
polymer, nanoparticle, microparticle, drug delivery system, bone tissue regeneration, Research Subject Categories::NATURAL SCIENCES::Chemistry, Research Subject Categories::NATURAL SCIENCES
Citation
Ogay, V., Mun, E. A., Kudaibergen, G., Baidarbekov, M., Kassymbek, K., Zharkinbekov, Z., & Saparov, A. (2020). Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration. Polymers, 12(12), 2881. https://doi.org/10.3390/polym12122881