Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening

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dc.contributor.authorPoddighe, Dimitri
dc.contributor.authorRebuffi, Chiara
dc.contributor.authorDe Silvestri, Annalisa
dc.contributor.authorCapittini, Cristina
dc.date.accessioned2020-05-06T10:25:08Z
dc.date.available2020-05-06T10:25:08Z
dc.date.issued2020-03-28
dc.description.abstractThe final output of this systematic search in the medical literature consisted of 38 studies providing the appropriate HLA-DQB1 genotype information of the respective CD population. According to this systematic review, including a pool of 4945 HLA-DQ genotyped CD patients, the HLA-DQB1*02 carrier frequency was 94.94%, meaning that only 5.06% of CD patients were completely lacking this allelic variant. Interestingly, if we consider only the studies whereby the prevalence of CD patients affected with type 1 diabetes mellitus was supposed or clearly established to be very low, the frequency of non-HLA-DQB1*02 carriers among CD patients dropped to 3.65%.en_US
dc.identifier.citationPoddighe D, Rebuffi C, De Silvestri A, Capittini C. Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening. World J Gastroenterol. 2020;26(12):1365‐1381. doi:10.3748/wjg.v26.i12.1365en_US
dc.identifier.uri10.3748/wjg.v26.i12.1365
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4603
dc.language.isoenen_US
dc.publisherBaishideng Publishing Groupen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectResearch Subject Categories::MEDICINE::Microbiology, immunology, infectious diseasesen_US
dc.titleCarrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screeningen_US
dc.typeArticleen_US
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