Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening
Loading...
Date
2020-03-28
Authors
Poddighe, Dimitri
Rebuffi, Chiara
De Silvestri, Annalisa
Capittini, Cristina
Journal Title
Journal ISSN
Volume Title
Publisher
Baishideng Publishing Group
Abstract
The final output of this systematic search in the medical literature consisted of 38 studies providing the appropriate HLA-DQB1 genotype information of the respective CD population. According to this systematic review, including a pool of 4945 HLA-DQ genotyped CD patients, the HLA-DQB1*02 carrier frequency was 94.94%, meaning that only 5.06% of CD patients were completely lacking this allelic variant. Interestingly, if we consider only the studies whereby the prevalence of CD patients affected with type 1 diabetes mellitus was supposed or clearly established to be very low, the frequency of non-HLA-DQB1*02 carriers among CD patients dropped to 3.65%.
Description
Keywords
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Citation
Poddighe D, Rebuffi C, De Silvestri A, Capittini C. Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening. World J Gastroenterol. 2020;26(12):1365‐1381. doi:10.3748/wjg.v26.i12.1365