BARIUM DOPED CARBON DOTS AS BIMODAL CT CONTRAST AGENTS
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Date
2021-04-16
Authors
Kairova, Meruyert
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University School of Sciences and Humanities
Abstract
In the past several decades computed tomography (CT) has been accepted as a useful tool for
bioimaging in medicine. The choice of a suitable contrast agent for CT that is low-cost, effective,
and has no side effects is very vital for modern medicine and highly challenging at the same
time. Recently, carbon-based quantum dots (CDs) have been proposed for radiological
applications thanks to their unique optical properties, low-cost production, non-toxicity,
colloidal and chemical stability. The main goal of this research work is to investigate Ba-CDs
for potential X-ray attenuation. Compared to widely used lanthanide elements such as Gd, Ba is
a much cheaper and naturally abundant element. In addition, Barium sulfate is already
commonly used as an X-ray attenuation contrast agent for gastrointestinal tract visualization. In
this thesis, we utilized a facile one-pot hydrothermal reaction to synthesize fluorescent CDs and
Ba-CDs from glucose and Ba(NO3)2. The samples were assessed by a range of characterization
techniques to evaluate their morphological, elemental, structural, optical, and CT X-ray
attenuation properties.
Description
Keywords
computed tomography, Type of access: Gated Access, carbon-based quantum dots, X-ray attenuation
Citation
Kairova, M. (2021). Barium doped carbon dots as bimodal CT contrast agents (Unpublished master`s thesis). Nazarbayev University, Nur-sultan, Kazakhstan