Sequential Delivery of Cryogel Released Growth Factors and Cytokines Accelerates Wound Healing and Improves Tissue Regeneration

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dc.contributor.authorShiro Jimi
dc.contributor.authorAlexandr Jaguparov
dc.contributor.authorAyan Nurkesh
dc.contributor.authorBolat Sultankulov
dc.contributor.authorArman Saparov
dc.date.accessioned2025-08-20T04:04:53Z
dc.date.available2025-08-20T04:04:53Z
dc.date.issued2020-01-01
dc.description.abstractGrowth factors and cytokines play crucial roles in tissue repair. This study investigated the effect of sequential, spatially and temporally controlled delivery of inflammation-modulatory (IL‑10, TGF‑β) and wound‑healing (VEGF, FGF) factors using a novel chitosan-based cryogel in a murine internal splint wound model. Cryogels with IL‑10 and TGF‑β were applied on day 0 and those with VEGF and FGF on day 3. This strategy significantly reduced wound area (to around 10 % by day 10 vs. 60–65 % in control), enhanced granulation tissue formation, neovascularization, and regenerative epithelialization, demonstrating accelerated healing and improved tissue regeneration., en
dc.identifier.citationJimi, S.; Jaguparov, A.; Nurkesh, A.; Sultankulov, B.; Saparov, A. (2020). Front. Bioeng. Biotechnol., 8:345. https://doi.org/10.3389/fbioe.2020.00345en
dc.identifier.doi10.3389/fbioe.2020.00345
dc.identifier.urihttps://doi.org/10.3389/fbioe.2020.00345
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/9662
dc.language.isoen
dc.publisherFrontiers
dc.relation.ispartofFrontiers in Bioengineering and Biotechnologyen
dc.rightsOpen accessen
dc.sourceFrontiers in Bioengineering and Biotechnology, 8, 345, (2020)en
dc.subjectcryogelen
dc.subjectgrowth factorsen
dc.subjectwound healingen
dc.subjecttissue regenerationen
dc.titleSequential Delivery of Cryogel Released Growth Factors and Cytokines Accelerates Wound Healing and Improves Tissue Regenerationen
dc.typeJournal Articleen

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