Role of membrane biophysics in Alzheimer’s–related cell pathways

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dc.contributor.authorZhu, Donghui
dc.contributor.authorBungart, BrittaniL
dc.contributor.authorYang, Xiaoguang
dc.contributor.authorZhumadilov, Zhaxybay
dc.contributor.authorLee, James C-M.
dc.contributor.authorAskarova, Sholpan
dc.date.accessioned2016-02-08T07:41:09Z
dc.date.available2016-02-08T07:41:09Z
dc.date.issued2015-05-27
dc.description.abstractP-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the development and progression of Alzhemer’s disease. In this study we have evaluated the effects of Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3). Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted actin polymerization, and these events were correlated with increased reactive oxygen species (ROS) generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent an important physiological trigger of the microvascular inflammation in Alzheimer disease.ru_RU
dc.identifier.citationZhu D,BungartBL,YangX, ZhumadilovZ,LeeJC-Mand Askarova S(2015)Roleofmembrane biophysics inAlzheimer’s–relatedcell pathways. Front.Neurosci.9:186. doi: 10.3389/fnins.2015.00186ru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1181
dc.language.isoenru_RU
dc.publisherFrontiers inNeuroscienceru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectamyloid-b peptideru_RU
dc.subjectmembrane molecular orderru_RU
dc.subjectamyloid precursor proteinru_RU
dc.subjectmembrane fluidityru_RU
dc.subjectcerebral endotheliumru_RU
dc.titleRole of membrane biophysics in Alzheimer’s–related cell pathwaysru_RU
dc.typeArticleru_RU

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