Role of membrane biophysics in Alzheimer’s–related cell pathways
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Date
2015-05-27
Authors
Zhu, Donghui
Bungart, BrittaniL
Yang, Xiaoguang
Zhumadilov, Zhaxybay
Lee, James C-M.
Askarova, Sholpan
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers inNeuroscience
Abstract
P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the
development and progression of Alzhemer’s disease. In this study we have evaluated the effects of Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3).
Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted actin polymerization, and these events were correlated with increased reactive oxygen species (ROS) generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent an important physiological trigger of the microvascular inflammation in Alzheimer disease.
Description
Keywords
amyloid-b peptide, membrane molecular order, amyloid precursor protein, membrane fluidity, cerebral endothelium
Citation
Zhu D,BungartBL,YangX, ZhumadilovZ,LeeJC-Mand Askarova S(2015)Roleofmembrane biophysics inAlzheimer’s–relatedcell pathways. Front.Neurosci.9:186. doi: 10.3389/fnins.2015.00186