Rapid liquid chromatography–tandem mass spectrometry method for the determination of a broad mixture of pharmaceuticals in surface water

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dc.contributor.authorConley, Justin
dc.contributor.authorSymes, Steven
dc.contributor.authorKindelberger, Scott
dc.contributor.authorRichards, Sean
dc.date.accessioned2016-11-21T05:51:12Z
dc.date.available2016-11-21T05:51:12Z
dc.date.issued2008
dc.description.abstractHerein, a new method for the detection of 13 different pharmaceuticals and one metabolite in surface water at low ng/L levels is described. The method utilizes ultra performance liquid chromatography–tandem mass spectrometry and a solid-phase extraction sample preparation. Mean method detection limits were low (4.10 ng/L) and overall solid-phase extraction recovery and reproducibility was adequate (mean recovery, 77.9%; mean RSD, 7.3%). The method allows for quick run times and minimal solvent use as compared with other previously reported high performance liquid chromatography-based methods. Application of this method for the detection of pharmaceuticals in Tennessee River surfacewater determined that caffeine, sulfamethoxazole, and carbamazepine were frequently detected (100% of samples). Trimethoprim was moderately detected (30% of samples); acetaminophen, atorvastatin, and lovastatin were infrequently detected (10% of samples); and ciprofloxacin, diltiazem, fluoxetine, levofloxacin, norfluoxetine, ranitidine, and sertraline were not detected. This study reports the first detection of lovastatin in surface water.ru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1901
dc.language.isoenru_RU
dc.publisherJournal of Chromatography A. www.sciencedirect.comru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectultra performance liquid chromatographyru_RU
dc.subjectsolid-phase extractionru_RU
dc.subjecttandem mass spectrometryru_RU
dc.subjectenvironmental analysisru_RU
dc.subjectsurface waterru_RU
dc.subjectpharmaceuticalru_RU
dc.titleRapid liquid chromatography–tandem mass spectrometry method for the determination of a broad mixture of pharmaceuticals in surface waterru_RU
dc.typeArticleru_RU

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