Rapid liquid chromatography–tandem mass spectrometry method for the determination of a broad mixture of pharmaceuticals in surface water
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Date
2008
Authors
Conley, Justin
Symes, Steven
Kindelberger, Scott
Richards, Sean
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Chromatography A. www.sciencedirect.com
Abstract
Herein, a new method for the detection of 13 different pharmaceuticals and one metabolite in surface water at low ng/L levels is described. The method utilizes ultra performance liquid chromatography–tandem mass spectrometry and a solid-phase extraction sample preparation. Mean method detection limits were low (4.10 ng/L) and overall solid-phase extraction recovery and reproducibility was adequate (mean recovery, 77.9%; mean RSD, 7.3%). The method allows for quick run times and minimal solvent use as compared with other previously reported high performance
liquid chromatography-based methods. Application of this method for the detection of pharmaceuticals in Tennessee River surfacewater determined
that caffeine, sulfamethoxazole, and carbamazepine were frequently detected (100% of samples). Trimethoprim was moderately detected (30% of samples); acetaminophen, atorvastatin, and lovastatin were infrequently detected (10% of samples); and ciprofloxacin, diltiazem, fluoxetine, levofloxacin, norfluoxetine, ranitidine, and sertraline were not detected. This study reports the first detection of lovastatin in surface water.
Description
Keywords
ultra performance liquid chromatography, solid-phase extraction, tandem mass spectrometry, environmental analysis, surface water, pharmaceutical