GUT MODULATION OF DYSBIOSIS INDUCED BY DEXTRAN SULFATE SODIUM

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dc.contributor.authorKozhakhmetov, Samat S.
dc.contributor.authorBabenko, Dmitriy
dc.contributor.authorKozhakhmetova, Saniya
dc.contributor.authorTuyakova, Altynay
dc.contributor.authorNurgaziyev, Madiyar
dc.contributor.authorNurgozhina, Ayaulym
dc.contributor.authorMuhanbetganov, Nurislam
dc.contributor.authorChulenbayeva, Laura
dc.contributor.authorSergazy, Shynggys
dc.contributor.authorGulyayev, Alexander
dc.contributor.authorTanabayev, Baimakhan
dc.contributor.authorSaliev, Timur
dc.contributor.authorKushugulova, Almagul R.
dc.date.accessioned2021-08-10T03:25:12Z
dc.date.available2021-08-10T03:25:12Z
dc.date.issued2021-06-08
dc.description.abstractInflammatory bowel disease is one of the serious burdens of clinical medicine and healthcare. This study investigated the potential of a biological product based on mare's milk and metabolites of symbiotic microflora for modulation of intestinal microflora affected by dextran sulfate sodium (DSS)-induced dysbiosis. Symbiotic microflora was isolated from the stool of healthy volunteers. Lysates for the production of short-chain fatty acids of screened microorganisms were mixed with mare's milk. The activity of the biological product was evaluated on the DSS model of induced colitis. Histological changes in the intestinal epithelium were determined. The structure of the microbiome was evaluated based on the analysis of 16S rRNA microbial sequences. Histological examination of rat intestinal tissues after application of the biological product showed reduced infiltration of granulocytes, macrophages, and lymphocytes. The results of sequencing demonstrated a decrease in the biological diversity of microbiota affected by colitis. The full recovery was observed after 21 days of the application of the biological product. The product induced the structural changes of the microbiome damaged by DSS. Likewise, the number of the pathogenic intestinal microflora was decreased Representatives of SCFA producing bacteria increased concentrations of genus Lactobacillus.en_US
dc.identifier.citationKozhakhmetov, S., Babenko, D., Kozhakhmetova, S., Tuyakova, A., Nurgaziyev, M., Nurgozhina, A., Muhanbetganov, N., Chulenbayeva, L., Sergazy, S., Gulyayev, A., Tanabayev, B., Saliev, T., & Kushugulova, A. (2021). Gut modulation of dysbiosis induced by dextran sulfate sodium. Food Bioscience, 42, 101167. https://doi.org/10.1016/j.fbio.2021.101167en_US
dc.identifier.issn2212-4292
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2212429221002923?via%3Dihub#!
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2021.101167
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5674
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofseriesFood Bioscience;Volume 42, August 2021, 101167
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectType of access: Open Accessen_US
dc.subjectBiological producten_US
dc.subjectDSS-Induced colitisen_US
dc.subjectGut microbiomeen_US
dc.subjectMicrobial diversityen_US
dc.subjectRatsen_US
dc.titleGUT MODULATION OF DYSBIOSIS INDUCED BY DEXTRAN SULFATE SODIUMen_US
dc.typeArticleen_US
workflow.import.sourcescience

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