Antiproliferative and Cytotoxic Activity of Geraniaceae Plant Extracts Against Five Tumor Cell Lines

Simple item page
dc.contributor.authorSergazy Shynggys
dc.contributor.authorVetrova Anastassiya
dc.contributor.authorOrhan Ilkay Erdogan
dc.contributor.authorSenol Deniz Fatma Sezer
dc.contributor.authorKahraman Ahmet
dc.contributor.authorZhang Jian_Ye
dc.contributor.authorAljofan Mohamad
dc.date.accessioned2024-10-31T07:16:50Z
dc.date.available2024-10-31T07:16:50Z
dc.date.issued2021
dc.description.abstractAim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species. Lay abstract Several plant species of the genera Geranium and Erodium were extracted and screened against five tumor cell lines for their potential antitumor activities. Out of the tested species, four showed potential antitumor action against all the tumor cells used. Interestingly, they appeared to achieve their antitumor activities by inducing important cellular defense mechanisms called autophagy and apoptosis. The current work is the first to test the antiproliferative potential of these species against different tumor cells.
dc.identifier.citationSergazy, S., Vetrova, A., Orhan, I. E., Deniz, F. S. S., Kahraman, A., Zhang, J., & Aljofan, M. (2021). Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines. Future Science OA, 8(2), Taylor & Francis. https://doi.org/10.2144/fsoa-2021-0109
dc.identifier.otherdoi: 10.2144/fsoa-2021-0109
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/8287
dc.language.isoen
dc.publisherTaylor & Francis
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.subjectanticancer
dc.subjectantiproliferative
dc.subjectbreast cancer
dc.subjectcytotoxicity
dc.subjectErodium
dc.subjectGeraniaceae
dc.subjectGeranium
dc.titleAntiproliferative and Cytotoxic Activity of Geraniaceae Plant Extracts Against Five Tumor Cell Lines
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Antiproliferative and Cytotoxic Activity of Geraniaceae Plant Extracts Against Five Tumor Cell Lines.pdf
Size:
1.59 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
6.28 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Articles