Antiproliferative and Cytotoxic Activity of Geraniaceae Plant Extracts Against Five Tumor Cell Lines
No Thumbnail Available
Date
2021
Authors
Sergazy Shynggys
Vetrova Anastassiya
Orhan Ilkay Erdogan
Senol Deniz Fatma Sezer
Kahraman Ahmet
Zhang Jian_Ye
Aljofan Mohamad
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.
Lay abstract
Several plant species of the genera Geranium and Erodium were extracted and screened against five tumor cell lines for their potential antitumor activities. Out of the tested species, four showed potential antitumor action against all the tumor cells used. Interestingly, they appeared to achieve their antitumor activities by inducing important cellular defense mechanisms called autophagy and apoptosis. The current work is the first to test the antiproliferative potential of these species against different tumor cells.
Description
Keywords
anticancer, antiproliferative, breast cancer, cytotoxicity, Erodium, Geraniaceae, Geranium
Citation
Sergazy, S., Vetrova, A., Orhan, I. E., Deniz, F. S. S., Kahraman, A., Zhang, J., & Aljofan, M. (2021). Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines. Future Science OA, 8(2), Taylor & Francis. https://doi.org/10.2144/fsoa-2021-0109