Alterations of oncogenes expression in human NK cells in cancer patients
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Date
2016-05
Authors
Amirbekov, A.
Eraliyeva, L.
Zakiryanova, G.
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Abstract
C-kit/SCF signaling play a key role in regulating NK cell homeostasis,
maturation, proliferation and cytotoxicity. C-kit-deficiency in NK results in significant reduction of
their, suggesting imperative role fore-kit signaling in NKcell immunobiology. We have recently
showed that human NK cells express not only c-kit-receptor, but also both membrane-bound
and soluble forms of c-kit ligand - Stem cell factor. The goal of this study was to characterize the
c-kit/SCF autocrine loop in peripheral blood NK cells obtained from patients with cancer.
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Keywords
NK cells, c-Kit, SCF, c-Myc, STAT3
Citation
A. Amirbekov, L. Eraliyeva, G. Zakiryanova. 2016. Alterations of oncogenes expression in human NK cells in cancer patients. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1499