HISTORY OF ENDOMETRIOSIS IS INDEPENDENTLY ASSOCIATED WITH AN INCREASED RISK OF OVARIAN CANCER
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Date
2022
Authors
Sarría-Santamera, Antonio
Khamitova, Zaukiya
Gusmanov, Arnur
Terzic, Milan
Polo-Santos, Mar
Ortega, Miguel A.
Asúnsolo, Angel
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Personalized Medicine
Abstract
Endometriosis is a complex gynecologic disorder that has been associated with
a higher risk of ovarian cancer. The purpose of this work is to determine to what extent a history of
endometriosis is a risk factor for ovarian cancer in a Spanish population. Methods: A retrospective
case–control study was conducted using de-identified data from the Spanish National Health System’s
“Primary Care Clinical Database” and “Hospital Minimum Basic Data Set” for the period 2013–2017.
Multiple logistics regression analysis was conducted to determine associations between ovarian
cancer and endometriosis controlled by sociodemographic characteristics and comorbidities. Results:
Data from 608,980 women were analyzed, with 4505 presenting ovarian cancer. Endometriosis
patients were shown to have a 2.66-fold increased risk of ovarian cancer when compared to those who
did not have endometriosis by controlling age and other relevant comorbidities. Conclusions: This
case–control study based on clinical administrative data has found that a history of endometriosis
is independently associated with an increased risk of ovarian cancer. More research is needed to
determine if a history of endometriosis affects survival results in ovarian cancer patients.
Description
Keywords
Type of access: Open Access, endometriosis, ovarian cancer, sociodemographic characteristics, risk
Citation
Sarría-Santamera, A., Khamitova, Z., Gusmanov, A., Terzic, M., Polo-Santos, M., Ortega, M. A., & Asúnsolo, Á. (2022). History of Endometriosis Is Independently Associated with an Increased Risk of Ovarian Cancer. Journal of Personalized Medicine, 12(8), 1337. https://doi.org/10.3390/jpm12081337