Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer

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dc.contributor.authorAlibek, Kenneth
dc.contributor.authorIrving, Stephanie
dc.contributor.authorSautbayeva, Zarina
dc.contributor.authorKakpenova, Ainur
dc.contributor.authorBekmurzayeva, Aliya
dc.contributor.authorBaiken, Yeldar
dc.contributor.authorImangali, Nurgul
dc.contributor.authorShaimerdenova, Madina
dc.contributor.authorMektepbayeva, Damel
dc.contributor.authorBalabiyev, Arnat
dc.contributor.authorChinybayeva, Aizada
dc.date.accessioned2018-11-01T10:58:37Z
dc.date.available2018-11-01T10:58:37Z
dc.date.issued2014
dc.description.abstractThe Bcl proteins play a critical role in apoptosis, as mutations in family members interfere with normal programmed cell death. Such events can cause cell transformation, potentially leading to cancer. Recent discoveries indicate that some viral proteins interfere with Bcl proteins either directly or indirectly; however, these data have not been systematically described. Some viruses encode proteins that reprogramme host cellular signalling pathways controlling cell differentiation, proliferation, genomic integrity, cell death, and immune system recognition. This review analyses and summarises the existing data and discusses how viral proteins interfere with normal pro- and anti-apoptotic functions of Bcl-2 and Bcl-xL. Particularly, this article focuses on how viral proteins, such as Herpesviruses, HTLV-1, HPV and HCV, block apoptosis and how accumulation of such interference predisposes cancer development. Finally, we discuss possible ways to prevent and treat cancers using a combination of traditional therapies and antiviral preparations that are effective against these viruses.en_US
dc.identifier.citationKenneth Alibek, Stephanie Irving, Zarina Sautbayeva, Ainur Kakpenova, Aliya Bekmurzayeva, Yeldar Baiken, Nurgul Imangali, Madina Shaimerdenova, Damel Mektepbayeva, Arnat Balabiyev and Aizada Chinybayeva. Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer. 2014. Infectious Agents and Canceren_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3600
dc.language.isoenen_US
dc.publisherInfectious Agents and Canceren_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectBcl-2en_US
dc.subjectBcl-xLen_US
dc.subjectHerpesvirusesen_US
dc.subjectHuman T-lymphotropic virusen_US
dc.subjectHuman papillomavirusen_US
dc.subjectHepatitis C virusen_US
dc.subjectApoptosisen_US
dc.subjectSignaling pathwaysen_US
dc.subjectTumor suppressor genesen_US
dc.subjectCanceren_US
dc.titleDisruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of canceren_US
dc.typeThesis of the employeeen_US
workflow.import.sourcescience

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