Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer
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Date
2014
Authors
Alibek, Kenneth
Irving, Stephanie
Sautbayeva, Zarina
Kakpenova, Ainur
Bekmurzayeva, Aliya
Baiken, Yeldar
Imangali, Nurgul
Shaimerdenova, Madina
Mektepbayeva, Damel
Balabiyev, Arnat
Journal Title
Journal ISSN
Volume Title
Publisher
Infectious Agents and Cancer
Abstract
The Bcl proteins play a critical role in apoptosis, as mutations in family members interfere with normal programmed
cell death. Such events can cause cell transformation, potentially leading to cancer. Recent discoveries indicate that
some viral proteins interfere with Bcl proteins either directly or indirectly; however, these data have not been
systematically described. Some viruses encode proteins that reprogramme host cellular signalling pathways
controlling cell differentiation, proliferation, genomic integrity, cell death, and immune system recognition.
This review analyses and summarises the existing data and discusses how viral proteins interfere with normal
pro- and anti-apoptotic functions of Bcl-2 and Bcl-xL. Particularly, this article focuses on how viral proteins, such as
Herpesviruses, HTLV-1, HPV and HCV, block apoptosis and how accumulation of such interference predisposes
cancer development. Finally, we discuss possible ways to prevent and treat cancers using a combination of traditional
therapies and antiviral preparations that are effective against these viruses.
Description
Keywords
Bcl-2, Bcl-xL, Herpesviruses, Human T-lymphotropic virus, Human papillomavirus, Hepatitis C virus, Apoptosis, Signaling pathways, Tumor suppressor genes, Cancer
Citation
Kenneth Alibek, Stephanie Irving, Zarina Sautbayeva, Ainur Kakpenova, Aliya Bekmurzayeva, Yeldar Baiken, Nurgul Imangali, Madina Shaimerdenova, Damel Mektepbayeva, Arnat Balabiyev and Aizada Chinybayeva. Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer. 2014. Infectious Agents and Cancer