CLONOGENIC CAPACITY OF CANCER CELLS AFTER MITOTIC SLIPPAGE
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Date
2023
Authors
Yeskendirova, Raushan
Journal Title
Journal ISSN
Volume Title
Publisher
School of Sciences and Humanities
Abstract
Microtubules are a vital part of eukaryotic cells that assist in many processes, such as cell motility, spreading, intracellular transport, and mitosis. They are polymer structures that comprise α- and β-tubulin heterodimers and form 13 protofilaments. Each α and β monomer has a GTP-binding site. However, GTP bound to the α-tubulin is trapped and never hydrolyzed, whereas GTP on the β-tubulin could be either in GTP- or GDP-bound form and, thus, is exchangeable. The hydrolysis of GTP on the β-tubulin site impacts the microtubular dynamics.
Description
Keywords
Type of access: Open Access, cancer cells, mitotic slippage, Clonogenic capacity
Citation
Yeskendirova, R. (2023). Clonogenic capacity of cancer cells after mitotic slippage. School of Sciences and Humanities