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Browsing School of Sciences and Humanities by Author "339dc89e-527c-473b-9a66-5723132a95f2"

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Browsing School of Sciences and Humanities by Author "339dc89e-527c-473b-9a66-5723132a95f2"

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  • Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots 
    Xie, Yingqiu; Kauanova, Sholpan; Fan, Haiyan; Sun, Qinglei; Nurkesh, Ayan; Lu, Jiang; Tursynkhan, Darkhan; Yang, Qing; Kassymbek, Aishabibi; Karibayev, Mirat; Duisenova, Korlan; Wang, Xiao; Manarbek, Limara; Maipas, Aisulu; Chen, Zhenbang; Balanay, Mannix P. (Nazarbayev University School of Sciences and Humanities, 2017-11-29)
    YAP is a downstream nuclear transcription factor of Hippo pathway which plays an essential role in development, cell growth, organ size and homeostasis. It was previously identified that elevation of YAP in genomics of ...
  • Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer 
    Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)
    Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
  • Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance 
    Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...