INVESTIGATING AUTOPHAGY AS A POTENTIAL PATHWAY OF ANTICANCER MECHANISM OF PHENFORMIN
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Date
2024
Authors
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Publisher
Nazarbayev University School of Medicine
Abstract
Phenformin, a representative of the biguanides class, is an anti-diabetic drug that was
withdrawn from the market due to its side effects profile is currently being investigated as a
potential anticancer agent. Autophagy is an evolutionary conserved mechanism of
lysosome-mediated catabolic breakdown of proteins, cellular compartments, and infectious agents
for maintaining homeostasis. Activation of autophagy in cancer cell could potentially be one of the
mechanisms of phenformin’s anticancer activity. This research aimed to establish the
antiproliferative activity of phenformin among different cancer cell lines and to study the effect of
phenformin on expression of proteins involved in autophagy in cervical cancer cells. Cervical
cancer is the fourth leading cause of cancer mortality as well as the fourth most diagnosed cancer
type in females. Our findings demonstrate that phenformin decreases the proliferation of various
cancer cell lines in a dose-dependent manner cells and may have an ability to increase autophagic
flux in cervical cancer cells.
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Keywords
Type of access: Embargo, phenformin, autophagy, anticancer, antiproliferative, cervical cancer
Citation
Khikhmetova, K. (2024). Investigating autophagy as a potential pathway of anticancer mechanism of Phenformin. Nazarbayev University School of Medicine