SYSTEMATIC REVIEW AND LINEAR REGRESSION ANALYSIS OF HUMAN PAPILLOMAVIRUS VACCINE COVERAGE: TAKING COUNTRY AS A UNIT OF STATISTICAL ANALYSIS

Abstract

Introduction: Human pappilomavirus is the leaing cause of cervical cancer among women globally despite being a vaccine preventable diseases. There is geographical difference in term of incedences and mortality. While the proportion of mortality is higher in Low middle income countries with more than 90% expecially in Eastern Europe and sub-Saharan Africa. However, advancement in care and screening with previous historical success rate of vaccination in most high income countries were associated with low mortality. However, in recent time there is declining in HPV vaccine uptake in this countries. Objective: The main objective was to find factors associated with Human Papillomavirus vaccine coverage. Methods: A Systematic review of the literature was done from January 2014 – February 2024. Also, Linear regression analysis was done with stata/MP version 18, to determine the association of countrywide factors with HPV vaccine coverage. Results: In the systematic review, there were no significant differences across identified studies in terms of HPV vaccine coverage, or age group. However, barriers did exist. The high-income countries were faced with out-of-pocket and misinformation while the upper-middle-income and lower-middle-income countries were faced with funding, safety concerns, lack of information, and national priorities on budgeting. On the other hand, regression analysis showed that there may be an association between education and an increasing proportion of gross domestic product on health with vaccine coverage. Conclusion: Overall, education, funding, and an increasing proportion of spending on health care may be associated with human papillomavirus vaccine coverage. However, no statistically significant association was observed with the skill Index, Gross National Income, Work experience Index, and Health Index.