SYNTHESIS, CHARACTERIZATION, RELEASE PROFILE, AND CYTOTOXIC EVALUATION OF DOXORUBICIN-CONJUGATED ORGANOSILICA NANOPARTICLES.

Imantay, Alua

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dc.contributor.author	Imantay, Alua
dc.date.accessioned	2024-05-03T19:58:23Z
dc.date.available	2024-05-03T19:58:23Z
dc.date.issued	2024
dc.identifier.citation	Imantay, A. (2024). Synthesis, Characterization, Release Profile, and Cytotoxic Evaluation of Doxorubicin-conjugated Organosilica Nanoparticles. Nazarbayev University School of Sciences and Humanities	en_US
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/7634
dc.description.abstract	Doxorubicin is an efficient drug used in cancer treatment that is associated with some serious side effects (in serious cases might lead to patients’ death). However, conjugating it with organosilica nanoparticles can solve this issue by allowing targeted drug delivery. In this research project, doxorubicin-conjugated organosilica nanoparticles were successfully synthesized. The in vitro release profile showed up to 64% release of the drug in the cancer cell environment. The in vitro toxicity studies were performed using MTT assay and after 72 hours treatment of human lung adenocarcinoma cells with drug conjugate it showed minimal viability of cancer cells.	en_US
dc.language.iso	en	en_US
dc.publisher	Nazarbayev University School of Sciences and Humanities	en_US
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	Type of access: Restricted	en_US
dc.subject	Organosilica nanoparticles	en_US
dc.subject	doxorubicin	en_US
dc.subject	drug delivery systems	en_US
dc.subject	doxorubicin release	en_US
dc.subject	MTT assay	en_US
dc.title	SYNTHESIS, CHARACTERIZATION, RELEASE PROFILE, AND CYTOTOXIC EVALUATION OF DOXORUBICIN-CONJUGATED ORGANOSILICA NANOPARTICLES.	en_US
dc.type	Bachelor's thesis	en_US
workflow.import.source	science