SYNTHETIC AMPHOTERIC CRYOGELS AS AN ANTIDOTE AGAINST ACUTE HEAVY METAL POISONING

Baimenov, Alzhan; Fakhradiyev, Ildar; Berillo, Dmitriy; Saliev, Timur; Mikhalovsky, Sergey; Nurgozhin, Talgat; Inglezakis, Vassilis J.

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dc.contributor.author	Baimenov, Alzhan
dc.contributor.author	Fakhradiyev, Ildar
dc.contributor.author	Berillo, Dmitriy
dc.contributor.author	Saliev, Timur
dc.contributor.author	Mikhalovsky, Sergey
dc.contributor.author	Nurgozhin, Talgat
dc.contributor.author	Inglezakis, Vassilis J.
dc.date.accessioned	2022-02-16T03:12:25Z
dc.date.available	2022-02-16T03:12:25Z
dc.date.issued	2021-12-15
dc.identifier.citation	Baimenov, A. Z., Fakhradiyev, I. R., Berillo, D. A., Saliev, T., Mikhalovsky, S. V., Nurgozhin, T. S., & Inglezakis, V. J. (2021). Synthetic amphoteric cryogels as an antidote against acute heavy metal poisoning. Molecules (Basel, Switzerland), 26(24), 7601. https://doi.org/10.3390/molecules26247601	en_US
dc.identifier.issn	1420-3049
dc.identifier.uri	https://doi.org/10.3390/molecules26247601
dc.identifier.uri	https://www.mdpi.com/1420-3049/26/24/7601
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/6045
dc.description.abstract	The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscopy. The use of the cryogel in the treatment of rats administered an LD50 dose of Cd(NO3)2, CsNO3, Sr(NO3)2, or HgCl2 in aqueous solution showed their high survival rate compared to the control group, which did not receive such treatment. The histological and chemical analysis of internal tissues and the biochemical analysis of the blood of the experimental animals showed the effectiveness of the cryogel in protecting the animals against the damaging effect of HMs on the organism comparable with unithiol, a chelating agent based on 2,3-dimercapto-1-propane sulfonic acid sodium salt (DMPS) approved for the treatment of acute poisoning with some heavy metals. Keywords: cryogel; antidote; DMPS; elimination; heavy metals	en_US
dc.language.iso	en	en_US
dc.publisher	MDPI	en_US
dc.relation.ispartofseries	Molecules (Basel, Switzerland);26(24), 7601. https://doi.org/10.3390/molecules26247601
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/us/	*
dc.subject	Type of access: Open Access	en_US
dc.subject	cryogel	en_US
dc.subject	antidote	en_US
dc.subject	DMPS	en_US
dc.subject	elimination	en_US
dc.subject	heavy metals	en_US
dc.title	SYNTHETIC AMPHOTERIC CRYOGELS AS AN ANTIDOTE AGAINST ACUTE HEAVY METAL POISONING	en_US
dc.type	Article	en_US
workflow.import.source	science