• INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE 

  Mitidieri, Emma; Vellecco, Valentina; Brancaleone, Vincenzo; Vanacore, Domenico; Manzo, Onorina L.; Martin, Emil; Sharina, Iraida; Krutsenko, Yekaterina; Monti, Maria Chiara; Morretta, Elva; Papapetropoulos, Andreas; Caliendo, Giuseppe; Frecentese, Francesco; Cirino, Giuseppe; Sorrentino, Raffaella; Bianca, Roberta d'Emmanuele di Villa; Bucci, Mariarosaria (British Journal of Pharmacology, 2021-04-30)

  l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. ...
• GIW and InCoB, two premier bioinformatics conferences in Asia with a combined 40 years of history 

  Schönbach, Christian; Horton, Paul; Yiu, Siu Ming; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2015)

  Knowledge discovery in bioinformatics thrives on joint and inclusive efforts of stakeholders. Similarly, knowledge dissemination is expected to be more effective and scalable through joint efforts. Therefore, the International ...
• InCoB2014: Mining Biological Data From Genomics for Transforming Industry and Health 

  Schönbach, Christian; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2014)

  The 13th International Conference on Bioinformatics (InCoB2014) was held for the first time in Australia, at Sydney, July 31-2 August, 2014. InCoB is the annual scientific gathering of the Asia-Pacific Bioinformatics Network ...
• InCoB2013 introduces Systems Biology as a major conference theme 

  Schönbach, Christian; Shen, Bairong; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2013-09)

  The Asia-Pacific Bioinformatics Network (APBioNet) held the first International Conference on Bioinformatics (InCoB) in Bangkok in 2002 to promote North-South networking. Commencing as a forum for Asia-Pacific researchers ...
• Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori 

  Turgimbayeva, Aigerim; Abeldenov, Sailau; Zharkov, Dmitry O.; Ishchenko, Alexander A.; Ramankulov, Yerlan; Saparbaev, Murat; Khassenov, Bekbolat (PLoS ONE, 2018-08-15)

  Apurinic/apyrimidinic (AP) endonucleases play critical roles in the repair of abasic sites and strand breaks in DNA. Complete genome sequences of Helicobacter pylori reveal that this bacterial specie has a single AP ...
• Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide Diversity 

  Shevtsova, Elena; Vergnaud, Gilles; Shevtsov, Alexandr; Shustov, Alexandr; Berdimuratova, Kalysh; Mukanov, Kasim; Syzdykov, Marat; Kuznetsov, Andrey; Lukhnova, Larissa; Izbanova, Uinkul; Filipenko, Maxim; Ramankulov, Yerlan (FRONTIERS MEDIA SA, 2019-08-13)

  We describe the genetic diversity of 1327 Brucella strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the Brucella melitensis ...
• Autoantibodies to tissue transglutaminase target epitopes dependent on residues in the N-terminal domain 

  Kozhakhmetova, A; Wyatt, R; Elvers, K; Emery, D; Williams, C; Annis, P; Lampasona, V; Gillespie, K; Williams, A (Coeliac UK's Research Conference, 2017-03-24)

  INTRODUCTION: Tissue transglutaminase (tTG), is the main autoantigen of coeliac disease (CD). Specific tTG epitopes, including N-and C-terminal sites as well as the catalytic triad, have been reported to be targeted by ...
• Type 1 Diabetes: Current Perspectives 

  Kozhakhmetova, A; Gillespie, KM (Methods in Molecular Biology, 2016)

  Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic ...
• A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. 

  Kozhakhmetova, A; Wyatt, RC; Caygill, C; Williams, C; Long, AE; Chandler, K; Aitken, RJ; Wenzlau, JM; Davidson, HW; Gillespie, KM; Williams, AJK (Clinical and Experimental Immunology, 2018-03-24)

  Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the ...
• A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro 

  Zeng, Zhengyang; Zhang, Qian; Hong, Wei; Xie, Yingqiu; Liu, Yun; Li, Wenxin; Wu, Yingliang; Cao, Zhijian (MDPI, 2016-04-27)

  Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). ...
• Oral administration of chitosan/DNA nanoparticles containing DNA coding for FVIII and FC IgG fragment or IL-10 for the modulation of immune responses to FVIII in hemophilia mice 

  Yerkesh, Zhadyra (Nazarbayev University School of Science and Technology, 2016)

  Hemophilia A is an X-linked bleeding disorder, which occurs due to deficiency of clotting protein FVIII. Current treatment involves regular lifelong infusion of recombinant or plasma-derived FVIII protein, which is ...
• Migration characteristics of cancer cells grown in embryonic microenvironment and under antiviral agents 

  Karapina, Orynbassar (Nazarbayev University School of Science and Technology, 2016)

  This study describes a method for investigating reprogramming of cancer cells using chicken embryo extract and dimishing cancer cell progressing with acyclovir and it was used as innovative approach to address whether ...
• Co-expression of FVIII with human IGG FC Fragment or mouse IL-10 in encapsulated G8 myoblast cells as a potential treatment of hemophilia A 

  Kanketayeva, Zhansaya (Nazarbayev University School of Science and Technology, 2016)

  In this master thesis study we have shown that recombination G8 myoblasts, encapsulated in alginate-PLL microcapsules can successfully secrete detectable levels of both Fc and IL-10 out of the capsules and sustain good ...
• Role of astrocyte aging in the pathogenesis of Alzheimer`s disease 

  Imangali, Nurgul (Nazarbayev University School of Science and Technology, 2016)

  In this study we presented in vitro model for replicative senescence of primary human astrocytes isolated from fetal brains
• Morphometric characteristics of cancer cells grown in embryonic microenvironment and under antiviral treatment 

  Shaimerdenova, Madina (Nazarbayev University School of Science and Technology, 2016)

  We describe here that both embryonic microenvironment treatment and antiviral treatment have the potential to serve as effective factors in changing morphometric characteristics of two highly aggressive cancer cell lines, ...
• Concentration dependent mitostatic effect and inhibition of cell motibility by different tubulin binding drugs-comparative study 

  Balabiyev, Arnat (Nazarbayev University School of Science and Technology, 2016)

  Here, we demonstrate the comparative effects of nocodazole, taxol and vinorelbine on mitotic progression and cell motility using mouse fibroblasts and three cancer cell lines
• Application of advanced molecular techniques for analyzing phytoplankton population in Burabay National Nature Park Resort 

  Sarsembekova, Assel (Nazarbayev University School of Science and Technology, 2016)

  In this work, the molecular techniques as DNA extraction, DNA quantification, PCR analysis were optimized and subsequent sequencing was performed on MiSeq platform (Illumina, USA). We aimed to apply molecular methods to ...
• Development of flow cytometry and microscopy techniques to monitor freshwater phytoplankton communities in Kazakhstani lakes 

  Dashkova, Veronika (Nazarbayev University School of Science and Technology, 2016)

  In this project, we tested an approach based on separating fluorescent viability and metabolic dyes between different excitation lasers in order to reach minimal spectral overlap with the autofluorescent signal using flow ...
• CFD Modeling of Chamber Filling in a Micro- Biosensor for Protein Detection 

  Islamov, Meiirbek; Sypabekova, Marzhan; Kanayeva, Damira; Rojas-Solórzano, Luis (Biosensors, 2017-10)

  Tuberculosis (TB) remains one of the main causes of human death around the globe. The mortality rate for patients infected with active TB goes beyond 50% when not diagnosed. Rapid and accurate diagnostics coupled with ...
• Discovery and Characterization of an Endogenous CXCR4 Antagonist 

  O., Zirafi; K-A., Kim; L., Ständker; K. B., Mohr; D., Sauter; A., Heigele; S. F., Kluge; E., Wiercinska; D., Chudziak; R., Richter; B., Moepps; P., Gierschik; V., Vas; H., Geiger; M., Lamla; T., Weil; T., Burster; A., Zgraja; F., Daubeuf; N., Frossard; Timo, Burster (Cell Reports, 2015-05-05)

  CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a ...

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