Protective effect of peptide vaccination in murine infection with influenza virus

Abstract

Vaccination is a major tool to protect people from seasonal infections of different strains of influenza virus that presently infects millions of individuals worldwide. Virus genome is highly polymorphic, and universal vaccine that protects against permanently changing virus is still under development. Despite notable differences between humans and rodents in the disease course, immunobiology and clinical evaluations, murine infectious models remain one of the major tools to test approaches for influenza vaccine development.