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Browsing NU Research Week: abstracts by Author "Askarova, Sholpan"

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Browsing NU Research Week: abstracts by Author "Askarova, Sholpan"

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  • Age-realted dementia in Kazahstan: adaptation of the 10/66 dementia research group population -based study protocol 
    Kaiyrlykyzy, A.; Adambekov, Sh.; Alimbetov, D.; Askarova, Sholpan (Nazarbayev University, 2014)
    Background. The prevalence of dementia is increasing worldwide as the population ages and affects 10 % of the population over 65 years old and 40 % of people over the age of 80.[1] In Kazakhstan, as well as in other ...
  • Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats 
    Tokay, T.; Rehberg, M.; Kirschstein, T.; Rohde, M.; Mueller, L.; Askarova, Sholpan; Kohling, R.; Zhumadilov, Z. (Nazarbayev University, 2014)
    The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission in the hippocampus, and cognitive ...
  • Cell therapeutic approaches for the treatment of experimentally induced liver fibrosis 
    Askarova, Sholpan; Umbayev, B.; Tsoy, A.; Bulanin, D.; Ongarbayeva, N.; Shalakhmetova, T. (Nazarbayev University, 2013)
    The results of our study provide evidence that HT improved animal survival and liver functions by generating an ectopic hepatic mass inside the Peyer’s patches. These observations point to the conclusion that hepatocyte ...
  • Differentiation of mesenchymal stem cells into hepatocytes 
    Ualiyeva, S.; Umbayev, B.; Masoud, A.; Askarova, Sholpan (Nazarbayev University, 2014)
    Acute and chronic liver diseases are common in Kazakhstan and other countries. These diseases are known to cause significant disability and death. In many cases, liver transplantation is the last resort for patients with ...
  • Isolation of primary human hepatocytes from cirrhotic liver 
    Ualiyeva, S.; Umbayev, B.; Donbay, A.; Askarova, Sholpan (Nazarbayev University, 2014)
    Chronic degenerative liver diseases are among most complex social, clinical and epidemiological health problems worldwide. This is due to the steady increase in the incidence and mortality of patients with this pathology. ...
  • Polymer coating enhances affinity of bone marrow-derived MSCS to bone 
    Yantsen, Y.; Askarova, Sholpan; Adambekov, S.; Murata, H.; Andersen, J.; D’Souza, S.; Edington, C.; Koepsel, R.; Russell, A. (Nazarbayev University, 2013)
    The polymer coated cells were shown to be stably attached to bone fragments for at least 2 hours, confirming the bone targeting potential of the polymer. Our next step will be to test this approach in rat model of osteoporosis ...
  • Rage targeted strategies for Alzheimer`s Amyloid B peptide include blood brain barrier dysfunctions 
    Askarova, Sholpan; Tsoy, A.; Lee, J.C-M. (Nazarbayev University, 2013)
    This study demonstrated that Aβ binding to RAGE at the CECs and astrocytes surface is required for NADPH oxidase complex assembling, resulting in subsequent ROS generation and phosphorylation of cPLA2α. Therefore, understanding ...
  • Research on the bio-distribution of interferon gamma-containing pharmacocytes 
    Ibrasheva, D.; Idrissova, D.; Umbayev, B.; Masoud, A.; Askarova, Sholpan (Nazarbayev University, 2014)
    Viral hepatitis B and C- is a widespread infectious disease of the liver and is a potential threat to human life. Treatment of HCV and HBV requires prolonged (parenteral or oral) administration of antiviral and ...
  • Role of ROS in AB42 mediated cell surface P-selectin expression and actin polymerization 
    Tsoy, A.; Askarova, Sholpan; Shalakhmetova, T.; Umbayev, B.; Adambekov, S.; Zhumadilov, Z. (Nazarbayev University, 2014)
    Blood-brain barrier dysfunction plays an important role in the onset and progression of Alzheimer's disease (AD). In the AD brains an increased deposition of A(3 in the cerebral vasculature has been found to correlate ...
  • Role of ROS in AB42 mediated cell surface p-selectin expression and actin polymerization 
    Tsoy, A.; Askarova, Sholpan; Shalakhmetova, T.; Umbayev, B.; Adambekov, S.; Zhumadilov, Z. (Nazarbayev University, 2013)
    The results of our study have indicated that Aβ42 induces expression of P-selectin on the surface of bEnd3 cells and promotes actin polymerization in a time dependent manner, and all these events correlate with ROS generation. ...
  • The Central Asian journal of global health to increase science productivity 
    Freese, K.; Shubnikov, E.; LaPorte, R.; Adambekov, S.; Askarova, Sholpan; Zhumadilov, Z.; Linkov, F. (Nazarbayev University, 2013)
    The Central Asian Journal of Global Health (CAJGH) is the first peer reviewed, open access journal in Central Asia (CA) aimed at those working in the areas of public health, medicine, and bioengineering. Specifically, it ...