Abstract:
Acute and chronic liver diseases are common in Kazakhstan and other countries. These
diseases are known to cause significant disability and death. In many cases, liver transplantation is the
last resort for patients with end stage liver disease, but it is an extremely expensive procedure and is
associated with many risks. The most important among them is an immune rejection. Autologous cell
transplantation is a potential therapeutic approach for liver regeneration and could become an alternative
to organ transplantation. In this regard, mesenchymal stem cells (MSCs) are a very attractive source for
differentiation into hepatocytes. These cells can be isolated from bone marrow and adipose tissue of the
patient and exponentially expanded in vitro. Transplantation of hepatocytes differentiated from MSCs
could become a new promising approach in treatment of the patients with chronic liver conditions.
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