DSpace Repository

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan

Show simple item record

dc.contributor.author Iskakova, Aisha N.
dc.contributor.author Romanova, Aliya A.
dc.contributor.author Aitkulova, Akbota M.
dc.contributor.author Sikhayeva, Nurgul S.
dc.contributor.author Zholdybayeva, Elena V.
dc.contributor.author Ramanculov, Erlan M.
dc.date.accessioned 2017-11-16T09:20:22Z
dc.date.available 2017-11-16T09:20:22Z
dc.date.issued 2016-01-19
dc.identifier.citation Iskakova Aisha N., 2016(January 19), Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan, BMC Genetics ru_RU
dc.identifier.uri DOI 10.1186/s12863-016-0329-x
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/2826
dc.description.abstract Background: Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may improve our understanding of individual differences in sensitivity or resistance to certain drugs, thereby helping to avoid adverse drug reactions (ADRs) in patients and improve the quality of therapies. Here, we aimed to analyse single nucleotide polymorphisms (SNPs) involved in the ADME of multiple drugs in Kazakhs from Kazakhstan. Results: A total of 158 SNPs involved in the ADME of various drugs were studied. We analysed 320 Kazakh DNA samples using OpenArray genotyping. Of the 158 SNPs, 75 were not found in heterozygous or homozygous variants. Comparative analysis among Kazakhs and world populations showed a fairly high percentage of population differentiation. Conclusion: These results provide further information for pharmacogenetic databases and may contribute to the development of personalized approaches and safer therapies for the Kazakh population. Moreover, these data provide insights into the different racial groups that may have contributed to the Kazakh population. ru_RU
dc.language.iso en ru_RU
dc.publisher BMC Genetics ru_RU
dc.rights Open Access - the content is available to the general public ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Kazakhstan ru_RU
dc.subject single nucleotide polymorphism ru_RU
dc.subject adsorption ru_RU
dc.subject distribution ru_RU
dc.subject metabolism ru_RU
dc.subject Excretion ru_RU
dc.subject OpenArray ru_RU
dc.subject Research Subject Categories::NATURAL SCIENCES::Biology ru_RU
dc.title Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan ru_RU
dc.type Article ru_RU


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Open Access - the content is available to the general public Except where otherwise noted, this item's license is described as Open Access - the content is available to the general public