Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan

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dc.contributor.authorIskakova, Aisha N.
dc.contributor.authorRomanova, Aliya A.
dc.contributor.authorAitkulova, Akbota M.
dc.contributor.authorSikhayeva, Nurgul S.
dc.contributor.authorZholdybayeva, Elena V.
dc.contributor.authorRamanculov, Erlan M.
dc.date.accessioned2017-11-16T09:20:22Z
dc.date.available2017-11-16T09:20:22Z
dc.date.issued2016-01-19
dc.description.abstractBackground: Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may improve our understanding of individual differences in sensitivity or resistance to certain drugs, thereby helping to avoid adverse drug reactions (ADRs) in patients and improve the quality of therapies. Here, we aimed to analyse single nucleotide polymorphisms (SNPs) involved in the ADME of multiple drugs in Kazakhs from Kazakhstan. Results: A total of 158 SNPs involved in the ADME of various drugs were studied. We analysed 320 Kazakh DNA samples using OpenArray genotyping. Of the 158 SNPs, 75 were not found in heterozygous or homozygous variants. Comparative analysis among Kazakhs and world populations showed a fairly high percentage of population differentiation. Conclusion: These results provide further information for pharmacogenetic databases and may contribute to the development of personalized approaches and safer therapies for the Kazakh population. Moreover, these data provide insights into the different racial groups that may have contributed to the Kazakh population.ru_RU
dc.identifier.citationIskakova Aisha N., 2016(January 19), Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan, BMC Geneticsru_RU
dc.identifier.uriDOI 10.1186/s12863-016-0329-x
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2826
dc.language.isoenru_RU
dc.publisherBMC Geneticsru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectKazakhstanru_RU
dc.subjectsingle nucleotide polymorphismru_RU
dc.subjectadsorptionru_RU
dc.subjectdistributionru_RU
dc.subjectmetabolismru_RU
dc.subjectExcretionru_RU
dc.subjectOpenArrayru_RU
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biologyru_RU
dc.titlePolymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstanru_RU
dc.typeArticleru_RU

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