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Identifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstan

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dc.contributor.author Hermosilla, Sabrina
dc.contributor.author You, Paul
dc.contributor.author Aifah, Angela
dc.contributor.author Abildayev, Tleukhan
dc.contributor.author Akilzhanova, Ainur
dc.contributor.author Kozhamkulov, Ulan
dc.contributor.author Muminov, Talgat
dc.contributor.author Darisheva, Meruert
dc.contributor.author Zhussupov, Baurzhan
dc.contributor.author Terlikbayeva, Assel
dc.contributor.author El-Bassel, Nabila
dc.contributor.author Schluger, Neil
dc.date.accessioned 2017-11-13T04:34:05Z
dc.date.available 2017-11-13T04:34:05Z
dc.date.issued 2017-03-01
dc.identifier.citation Hermosilla Sabrina et al.(>11), 2017(March 1), Identifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstan, PLoS ONE, ru_RU
dc.identifier.uri doi:10.1371/journal. pone.0172942
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/2780
dc.description.abstract Background Sputum smear-positive tuberculosis (TB) patients have a high risk of transmission and are of great epidemiological and infection control significance. Little is known about the smearpositive populations in high TB burden regions, such as Kazakhstan. The objective of this study is to characterize the smear-positive population in Kazakhstan and identify associated modifiable risk factors. Methods Data on incident TB cases' (identified between April 2012 and March 2014) socio-demographic, risk behavior, and comorbidity characteristics were collected in four regions of Kazakhstan through structured survey and medical record review. We used multivariable logistic regression to determine factors associated with smear positivity. Results Of the total sample, 193 (34.3%) of the 562 study participants tested smear-positive. In the final adjusted multivariable logistic regression model, sex (adjusted odds ratio (aOR) = 2.0, 95% CI:1.3±3.1, p < 0.01), incarceration (aOR = 3.6, 95% CI:1.2±11.1, p = 0.03), alcohol dependence (aOR = 2.6, 95% CI:1.2±5.7, p = 0.02), diabetes (aOR = 5.0, 95% CI:2.4±10.7, p < 0.01), and physician access (aOR = 2.7, 95% CI:1.3±5.5p < 0.01) were associated with smear-positivity. Conclusions Incarceration, alcohol dependence, diabetes, and physician access are associated with smear positivity among incident TB cases in Kazakhstan. To stem the TB epidemic, screening, treatment and prevention policies should address these factors. ru_RU
dc.language.iso en ru_RU
dc.publisher PLoS ONE ru_RU
dc.rights Open Access - the content is available to the general public ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject pulmonary tuberculosis ru_RU
dc.subject sputum smear-positive tuberculosis ru_RU
dc.subject Kazakhstan ru_RU
dc.title Identifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstan ru_RU
dc.type Article ru_RU


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