Browsing Articles by Subject "AP endonuclease"

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Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases

Talhaoui, Ibtissam; Matkarimov, Bakhyt T.; Tchenio, Thierry; Zharkov, Dmitry O.; Saparbaev, Murat K. (Free Radical Biology and Medicine, 2017-06-01)

Abstract In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T and C, except for minor DNA base modifications such as methylation which serves for defence against foreign DNA or gene ...
Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA

Redrejo-Rodríguez, Modesto; Vigouroux, Armelle; Mursalimov, Aibek; Grin, Inga; Alili, Doria; Koshenov, Zhanat; Akishev, Zhiger; Maksimenko, Andrei; Bissenbaev, Amangeldy K.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Ishchenko, Alexander A.; Moréra, Solange (Biochimie, 2016-09-01)

Abstract Oxidatively damaged DNA bases are substrates for two overlapping repair pathways: DNA glycosylase-initiated base excision repair (BER) and apurinic/apyrimidinic (AP) endonuclease-initiated nucleotide incision ...