Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage

Abstract

Correction of phenotypic plasticity of macrophages for reprogramming inflammatory response is of great interest to modern medicine. To date, there are lots of factors, which can alter macrophages' phenotype to M1 or M2. The introduction of drug containing autologous erythrocyte ghosts is one of such factors. We have developed a method for the targeted delivery of autologous erythrocyte ghosts loaded with antibiotic (pharmacocytes) directly into the wound tissues. Introduction of pharmacocytes to the purulent wound ensures high therapeutic concentrations of the antibiotic, which leads to rapid arresting of the phase of the inflammatory process and thus results in early healing. In order to explain this phenomenon, we investigated the effect of the pharmacocytes on the phenotypic polarization of macrophages.