Browsing 02.National Laboratory Astana by Author "Sheng, Wenwen"

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Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes

Yang, Xiaoguang; Askarova, Sholpan; Sheng, Wenwen; Chen, JK; Sun, Albert Y.; Sun, Grace Y.; Yao, Gang; Leea, James C-M. (US National Library of Medicine National Institutes of Health, 2010-09-25)

Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, ...
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells

Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M. (Neuroscience. Author manuscript; available in PMC, 2012-12-29)

Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...